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The minimal set of components of the γ-secretase complex.Topological models of human PS1, NCT, APH-1 and PEN-2 (left) showing the domains which have been experimentally determined to be critical for the assembly and/or activity of the γ-secretase complex (rigth). The transmembrane domains (TMDs) are shown as cylinders, stars represent the two catalytic aspartates (D257 and D385) in human PS1, and asterisks represent TMDs with N- or C-terminal regions immediately adjacent to them.
