Table 3.

Ontology occurrence count in sentences from the test corpus, separated by diabetes and cancer phenotypes

Gene and protein perturbations	Cancer	Diabetes		Cancer	Diabetes
Total increasing modifications	266	586	Total decreasing modifications	267	110
General increasing modifications			General decreasing modifications
Activation	66	12	Down-regulated, -ion	12	0
Administered, -ion	7	120	Inactivation	5	0
Dose, -age, -dependent	11	86	Inhibition	30	7
Ectopic	7	0	Repression	1	0
Enhanced … expression	10	0	Suppression	10	3
Exogenous	6	23	DNA decreasing modifications
i.c.v.	0	11	Deficiency, -ent	15	12
i.p.	0	7	Deletion	3	2
Increased	26	18	Dominant-negative	3	0
Induction	8	2	Knockout	1	2
Infused, -ion	0	35	Loss	12	13
Injected, -ion	7	66	Mutant	0	0
Intracerebroventricular	0	51	Mutated, -ion	0	3
Intraperitoneal	1	16	mRNA decreasing modifications
mg/kg,/kg	0	8	Anti(-)sense	9	3
Oral	6	4	Interference	5	1
Overexpressed, -ration	38	0	Interfering RNA	2	0
Peripherally	0	7	Knockdown	12	0
Recombinant	7	10	RNA interference	4	0
Restoration	2	0	RNAi	2	0
Subcutaneous	0	2	Short hairpin RNA	1	0
Systemic	1	9	Silenced	1	0
Treatment	24	22	siRNA	15	0
Up-regulation	8	0	Protein decreasing modifications
DNA increasing modifications			Antagonist	7	28
Adenoviral	2	1	Anti-	25	4
Adenovirus	0	0	Antibody, -ies	11	3
Gain-of-function	2	0	Blockade, -ing	12	8
Gene delivery	1	3	Deactivation	1	0
Transgenic	3	2	Decoy	2	0
mRNA increasing modifications			Fc-	0	0
Inducible	2	0	Inhibitor	53	15
Protein increasing modifications			Inverse agonist	0	1
Activator	10	0	mAbs	1	0
Agonist	9	54	Neutralization	1	0
Analog/analogue	2	7	Reduced … activity	1	5
			Soluble	4	0
			Targeting	6	0

Note that total increased and decreased perturbations exceeds values in Table 2 since multiple perturbation terms may appear in a single sentence.