Table 3.
Gene and protein perturbations | Cancer | Diabetes | Cancer | Diabetes | |
---|---|---|---|---|---|
Total increasing modifications | 266 | 586 | Total decreasing modifications | 267 | 110 |
General increasing modifications | General decreasing modifications | ||||
Activation | 66 | 12 | Down-regulated, -ion | 12 | 0 |
Administered, -ion | 7 | 120 | Inactivation | 5 | 0 |
Dose, -age, -dependent | 11 | 86 | Inhibition | 30 | 7 |
Ectopic | 7 | 0 | Repression | 1 | 0 |
Enhanced … expression | 10 | 0 | Suppression | 10 | 3 |
Exogenous | 6 | 23 | DNA decreasing modifications | ||
i.c.v. | 0 | 11 | Deficiency, -ent | 15 | 12 |
i.p. | 0 | 7 | Deletion | 3 | 2 |
Increased | 26 | 18 | Dominant-negative | 3 | 0 |
Induction | 8 | 2 | Knockout | 1 | 2 |
Infused, -ion | 0 | 35 | Loss | 12 | 13 |
Injected, -ion | 7 | 66 | Mutant | 0 | 0 |
Intracerebroventricular | 0 | 51 | Mutated, -ion | 0 | 3 |
Intraperitoneal | 1 | 16 | mRNA decreasing modifications | ||
mg/kg,/kg | 0 | 8 | Anti(-)sense | 9 | 3 |
Oral | 6 | 4 | Interference | 5 | 1 |
Overexpressed, -ration | 38 | 0 | Interfering RNA | 2 | 0 |
Peripherally | 0 | 7 | Knockdown | 12 | 0 |
Recombinant | 7 | 10 | RNA interference | 4 | 0 |
Restoration | 2 | 0 | RNAi | 2 | 0 |
Subcutaneous | 0 | 2 | Short hairpin RNA | 1 | 0 |
Systemic | 1 | 9 | Silenced | 1 | 0 |
Treatment | 24 | 22 | siRNA | 15 | 0 |
Up-regulation | 8 | 0 | Protein decreasing modifications | ||
DNA increasing modifications | Antagonist | 7 | 28 | ||
Adenoviral | 2 | 1 | Anti- | 25 | 4 |
Adenovirus | 0 | 0 | Antibody, -ies | 11 | 3 |
Gain-of-function | 2 | 0 | Blockade, -ing | 12 | 8 |
Gene delivery | 1 | 3 | Deactivation | 1 | 0 |
Transgenic | 3 | 2 | Decoy | 2 | 0 |
mRNA increasing modifications | Fc- | 0 | 0 | ||
Inducible | 2 | 0 | Inhibitor | 53 | 15 |
Protein increasing modifications | Inverse agonist | 0 | 1 | ||
Activator | 10 | 0 | mAbs | 1 | 0 |
Agonist | 9 | 54 | Neutralization | 1 | 0 |
Analog/analogue | 2 | 7 | Reduced … activity | 1 | 5 |
Soluble | 4 | 0 | |||
Targeting | 6 | 0 |
Note that total increased and decreased perturbations exceeds values in Table 2 since multiple perturbation terms may appear in a single sentence.