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. 2008 Dec 15;37(3):793–803. doi: 10.1093/nar/gkn985

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Sequence-specific repression by CpGs associated with CTCF sites in the ICR. (A) Logarithmic graph of the relative repression of methylated plasmids in stable transfections of F9 cells. (B) Graph of the relative repression of methylated plasmids in stable transfections of NIH3T3 cells. (C) Expression of unmethylated reporter plasmids relative to unmethylated pCpGfree in stable transfections of F9 (empty) and 3T3 cells (gray). (A–C) Mean values and standard deviations below the graphs are from three independent experiments. All means have P-values < 0.05 when compared with unmethylated control plasmids, except where indicated by asterisk. Methylated sequences are indicated below the graphs. Sequences: Shift1, CpG-Shift1; Shift2, CpG-Shift2, ΔCpG1, ICR-ΔCpG1; ΔCpG2, ICR-ΔCpG2; Mut5, ICR-Mut5.