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. 2008 Dec 26;37(3):972–982. doi: 10.1093/nar/gkn968

Figure 1.

Figure 1.

Molecular structure of TBA and scheme of nanopore detection method. (a) Left, the sequence and structure of TBA G-quadruplex; right, the two G-tetrad planes in the TBA G-quadruplex (DOI 10.2210/pdb1c38/pdb, RCSB Protein Data Bank) (34), with the top tetrad formed by guanines at the position 1, 6, 10 and 15, and the bottom one by guanine 2, 5, 11 and 14. A cation in between is coordinated with eight carbonyls. The cation-carbonyl distance, d, is the one half the mean of inter-carbonyl distances between G1–G11, G2–G10, G5–G15 and G6–G14. d = 2.86 ± 0.7 Å. (b) Diagram of the current trace showing characteristic signature blocks. (c) Long-lived block for capturing a single G-quadruplex in the nanocavity enclosed by the α-hemolysin (αHL) pore; (d) The long block terminal spike produced by translocation of the unfolded G-quadruplex in the nanocavity. (e) Short-lived block formed by translocation of linear form TBA.