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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Neuropharmacology. 2008 Jul 22;56(Suppl 1):63–72. doi: 10.1016/j.neuropharm.2008.07.019

Figure 1.

Figure 1

Previous experience with cocaine, via either self-administration training (A), or non-contingent injections (B), disrupts reversal learning. Self-administration training included 14 daily 3-hour sessions, with 0.75 mg/kg cocaine-HCl per infusion and an average of 24 infusions per day, and ended at least one month prior to behavioral testing on the go, no-go odor discrimination task described in the text. Non-contingent injection regimen consisted of 14 once-daily IP injections of 30 mg/kg cocaine-HCl, also ending at least one month prior to behavioral testing. In testing, rats first showed retention of a previously learned odor discrimination, and then acquired a reversal of that odor discrimination. Shown are average trials to criterion for two (A) or three (B) serial retention/reversals. Error bars indicate SEMs. *, p < 0.01, compared to controls. Data adapted from Calu et al., Learning & Memory 2007, and Stalnaker et al., Neuron, 2007.