Table 1.

Sample size scenarios

Blood loss ≥ 1000 ml with full amtsl	Blood loss ≥ 1000 ml with Expectant	Estimated impact of Full AMTSL	Proportion (of full AMTSL effect) retained by the simplified package	Δ (Difference to exclude to claim equivalence)	Total N for 80% Power	Power with total N = 20,000	Power with total N = 25,000
1.5	3.0	1.5	0.7	0.45	22,908	75%	83%
1.5	3.5	2.0	0.75	0.50	18,555	83%	90%
1.5	4.0	2.5	0.8	0.50	18,555	83%	90%