TABLE 1.
DIAGNOSTIC CRITERIA OF A PULMONARY EXACERBATION*
| Fuchs and colleagues, Pulmozyme: |
| “Exacerbation of respiratory symptoms”: a patient treated with parenteral antibiotics for any 4 of the following 12 signs or symptoms: |
| –Change in sputum |
| –New or increased hemoptysis |
| –Increased cough |
| –Increased dyspnea |
| –Malaise, fatigue, or lethargy |
| –Temperature above 38°C |
| –Anorexia or weight loss |
| –Sinus pain or tenderness |
| –Change in sinus discharge |
| –Change in physical examination of the chest |
| –Decrease in pulmonary function by 10% or more from a previously recorded value |
| –Radiographic changes indicative of pulmonary infection |
| Ramsey and colleagues, inhaled tobramycin: |
| Pulmonary exacerbation indicated by at least two of the following seven symptoms during the study: |
| –Fever (oral temperature >38°C) |
| –More frequent coughing (increase of 50%) |
| –Increased sputum volume (increase of 50%) |
| –Loss of appetite |
| –Weight loss of at least 1 kg |
| –Absence from school or work (at least 3 or preceding 7 days) due to illness |
| –Symptoms of upper RTI |
| These symptoms had to have been associated with at least one of the following three additional criteria: |
| –Decrease in FVC of at least 10% |
| –An increase in respiratory rate of at least 10 breaths/min |
| –A peripheral blood neutrophil count of ⩾15,000/mm3 |