TABLE 1.
SUMMARY OF HLA ASSOCIATION STUDIES OF SARCOIDOSIS
| HLA | Risk Alleles | Finding | Reference |
|---|---|---|---|
| HLA-A | A*1 | Susceptibility | 126 |
| HLA-B | B*8 | Susceptibility in several populations | 8, 9, 127 |
| HLA-DPB1 | *0201 | Not associated with sarcoidosis | 16,19 |
| HLA-DQB1 | *0201 | Protection, Löfgren's syndrome, mild disease in several populations | 15, 128 |
| *0602 | Susceptibility/disease progression in several groups | 15, 129 | |
| HLA-DRB1 | *0301 | Acute onset/good prognosis in several groups | 9, 127, 130 |
| *04 | Protection in several populations | 126 | |
| *1101 | Susceptibility in whites and African Americans. Stage II/III chest X-ray | 13 | |
| HLA-DRB3 | *1501 | Associated with Löfgren's syndrome | 13, 129 |
| *0101 | Susceptibility/disease progression in whites | 131 |