TABLE 1.
DESCRIPTION OF GENOTYPIC AND PHENOTYPIC DATABASES
| Phenomic Databases | Description |
|---|---|
| MGI | Mouse Genome Informatics (MGI) provides integrated access to data on the genetics, genomics, phenomics, and biology of the laboratory mouse. |
| OMIM | The Online Mendelian Inheritance in Man (OMIM) is a database that catalogs relationships between human genes and genetic disorders. |
| OMIA | The Online Mendelian Inheritance in Animals (OMIA) is a database that catalogs genes, inherited disorders, and traits in more than 135 animal species (other than human and mouse). |
| PhenoGO | The PhenoGO is a computed database that provides phenotypic contexts and their associated GO terms for multiple organisms, including human, mouse, and rat. |
| PhenomicDB | The PhenomicDB is a multiorganism phenotype–genotype database, which is built by integrating data from several model organism databases. |
| Genetic Association Database | The Genetic Association Database archives human genetic association studies on complex diseases and disorders. |
| GeneCards | The GeneCards is a database of human genes with their associated genomic, proteomic, single nucleotide polymorphism, and disease information. |
| QMR-OMIM | This database integrates clinical knowledge and genomic data to define human trait–disease–gene relationships. |
| Mining OMIM | This study used OMIM to study relationships between human disease and genes. |
| GenesTrace | The GenesTrace defines ontology-anchored phenotypes from the UMLS and their statistical and semantic relationships to GO and model organism databases. |
| UMLS-GEO network | This study defines highly related phenotypic concepts and gene expressions by integrating phenotypically related concepts in UMLS and the microarray gene expression data from the NCBI's Gene Expression Omnibus (GEO). |
| Literature-based techniques | These methods mine literature by high-throughput computational method to identify relations between genes and unconstrained phenotypic contexts. |
Definition of abbreviations: NCBI = National Center for Biotechnology Information; QMR = Quick Medical Reference; UMLS = Unified Medical Language System.