TABLE 2.
MOUSE HOMOLOGS OF THE GENES IN TABLE 1 (DIFFERENTIALLY EXPRESSED IN PULMONARY FIBROSIS) AND SEEN RESPONSIVE TO BLEOMYCIN EXPOSURE IN C57 MICE
| Time Compared with Saline Exposure
|
|||||
|---|---|---|---|---|---|
| Time of Maximum Deviation from Saline | Symbol | 1 d | 3 d | 2 wk | Name |
| 1 d | Gdf15 | 35.6 | 12.8 | 2.2 | Growth differentiation factor 15 |
| Ccng1 | 4.1 | 3.8 | 1.2 | Cyclin G1 | |
| Robo1 | 0.2 | 1.0 | 1.1 | Roundabout homolog 1 (Drosophila) | |
| Thbs2 | 0.2 | 0.3 | 1.9 | Thrombospondin 2 | |
| 3 d | Apod | 2.2 | 4.8 | 3.2 | Apolipoprotein D |
| Plat | 1.0 | 2.3 | 1.6 | Plasminogen activator, tissue | |
| Sftpc | 1.2 | 0.3 | 2.1 | Surfactant-associated protein C | |
| 2 wk | Tnc | 1.8 | 4.0 | 9.2 | Tenascin C |
| Spp1 | 1.0 | 4.2 | 6.7 | Secreted phosphoprotein 1 | |
| Col3a1 | 1.2 | 2.5 | 5.0 | Procollagen, type III, alpha 1 | |
| Igf1 | 1.3 | 1.3 | 5.0 | Insulin-like growth factor 1 | |
| Col5a2 | 0.9 | 2.4 | 4.3 | Procollagen, type V, alpha 2 | |
| Cxcl12 | 2.0 | 2.3 | 2.9 | Chemokine (C-X-C motif) ligand 12 | |
| Cyp1b1 | 0.5 | 2.1 | 2.7 | Cytochrome P450, family 1, subfamily b, polypeptide 1 | |
| Col6a3 | 0.7 | 1.2 | 2.6 | Procollagen, type VI, alpha 3 | |
| Srpx | 1.0 | 1.1 | 2.6 | Sushi-repeat–containing protein | |
| Cxcl14 | 2.0 | 1.2 | 2.3 | Chemokine (C-X-C motif) ligand 14 | |
| Itgav | 1.3 | 0.8 | 0.5 | Integrin alpha V | |
| Timp1 | 1.7 | 2.1 | 0.4 | Tissue inhibitor of metalloproteinase 1 | |
| Prpf4b | 0.9 | 1.0 | 0.4 | PRP4 pre-mRNA processing factor 4 homolog B (yeast) | |
The genes listed show at least twofold deviation from the average in saline-exposed (C57) mice at any of the time points (1 d, 3 d, or 2 wk). Most genes are seen most strongly up-regulated at the latest (2 wk) time point. The most highly up-regulated gene, Gdf15, is involved in the injury response in liver and lung.