TABLE 3.
Erythrocyte fatty acid concentrations among women in Shanghai, China, and risk of nonproliferative fibrocystic conditions (NPFCs) with or without breast cancer (BC)1
| Quartiles of erythrocyte fatty acid concentrations |
|||||
| 1 | 2 | 3 | 4 | P for trend | |
| % of total by wt | |||||
| Palmitic acid (16:0) | 0 < n ≤ 18.16 | 18.16 < n ≤ 18.70 | 18.70 < n ≤ 19.27 | 19.27 < n | — |
| NPFCs alone vs control | 1.00 | 1.49 (0.70, 3.19)2 | 1.06 (0.49, 2.29) | 2.43 (1.17, 5.05) | 0.02 |
| NPFCs with BC vs control | 1.00 | 1.13 (0.45, 2.84) | 1.51 (0.64, 3.55) | 2.62 (1.16, 5.93) | 0.002 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.62 (0.22, 1.72) | 1.20 (0.45, 3.19) | 1.10 (0.44, 2.77) | 0.31 |
| Palmitoleic acid (16:1n–7) | 0 < n ≤ 0.13 | 0.13 < n ≤ 0.17 | 0.17 < n ≤ 0.24 | 0.24 < n | — |
| NPFCs alone vs control | 1.00 | 1.36 (0.74, 2.53) | 2.78 (1.49, 5.19) | 2.35 (1.19, 4.64) | 0.002 |
| NPFCs with BC vs control | 1.00 | 1.34 (0.63, 2.83) | 4.52 (2.22, 9.20) | 4.29 (2.07, 8.85) | <0.0001 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.94 (0.40, 2.22) | 1.40 (0.64, 3.09) | 1.81 (0.79, 4.15) | 0.07 |
| Oleic acid (18:1n–9c) | 0 < n ≤ 9.81 | 9.81 < n ≤ 10.38 | 10.38 < n ≤ 11.02 | 11.02 < n | — |
| NPFCs alone vs control | 1.00 | 0.67 (0.39, 1.15) | 0.59 (0.33, 1.08) | 0.93 (0.47, 1.83) | 0.36 |
| NPFCs with BC vs control | 1.00 | 1.00 (0.56, 1.79) | 1.12 (0.63, 2.02) | 1.44 (0.73, 2.85) | 0.32 |
| NPFCs with BC vs NPFCs alone | 1.00 | 1.18 (0.62, 2.26) | 1.70 (0.84, 3.45) | 1.28 (0.58, 2.81) | 0.27 |
| Vaccenic acid (18:1n–7) | 0 < n ≤ 0.85 | 0.85 < n ≤ 0.93 | 0.93 < n ≤ 1.01 | 1.01 < n | — |
| NPFCs alone vs control | 1.00 | 1.35 (0.75, 2.45) | 1.98 (1.06, 3.69) | 1.27 (0.65, 2.49) | 0.25 |
| NPFCs with BC vs control | 1.00 | 1.54 (0.81, 2.91) | 1.97 (1.04, 3.71) | 2.49 (1.29, 4.79) | 0.005 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.93 (0.45, 1.95) | 1.24 (0.59, 2.63) | 1.49 (0.67, 3.31) | 0.22 |
| n–6 PUFAs3 | 0 < n ≤ 26.61 | 26.61 < n ≤ 27.76 | 27.76 < n ≤ 29.48 | 29.48 < n | — |
| NPFCs alone vs control | 1.00 | 0.88 (0.50, 1.56) | 1.24 (0.71, 2.18) | 0.93 (0.45, 1.95) | 0.71 |
| NPFCs with BC vs control | 1.00 | 0.70 (0.40, 1.22) | 0.57 (0.31, 1.04) | 0.87 (0.44, 1.73) | 0.35 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.86 (0.44, 1.70) | 0.57 (0.29, 1.15) | 1.44 (0.61, 3.37) | 0.91 |
| Linoleic acid (18:2) | 0 < n ≤ 10.19 | 10.19 < n ≤ 11.40 | 11.40 < n ≤ 13.63 | 13.63 < n | — |
| NPFCs alone vs control | 1.00 | 0.75 (0.42, 1.32) | 1.24 (0.70, 2.23) | 0.78 (0.37, 1.64) | 0.9 |
| NPFCs with BC vs control | 1.00 | 0.67 (0.38, 1.17) | 0.53 (0.28, 0.99) | 0.83 (0.42, 1.66) | 0.27 |
| NPFCs with BC vs NPFCs alone | 1.00 | 1.35 (0.68, 2.68) | 0.64 (0.31, 1.32) | 1.28 (0.56, 2.95) | 0.78 |
| γ-Linolenic acid (18:3n–6) | 0 < n ≤ 0.05 | 0.05 < n ≤ 0.07 | 0.07 < n ≤ 0.09 | 0.09 < n | — |
| NPFCs alone vs control | 1.00 | 0.75 (0.45, 1.26) | 0.78 (0.39, 1.57) | 1.05 (0.54, 2.05) | 0.98 |
| NPFCs with BC vs control | 1.00 | 0.87 (0.49, 1.53) | 1.20 (0.59, 2.43) | 1.78 (0.93, 3.38) | 0.05 |
| NPFCs with BC vs NPFCs alone | 1.00 | 1.14 (0.60, 2.18) | 1.43 (0.63, 3.25) | 2.24 (1.07, 4.67) | 0.03 |
| Arachidonic acid (20:4) | 0 < n ≤ 11.43 | 11.43 < n ≤ 12.17 | 12.17 < n ≤ 12.92 | 12.92 < n | — |
| NPFCs alone vs control | 1.00 | 0.79 (0.44, 1.45) | 0.89 (0.48, 1.63) | 0.78 (0.43, 1.44) | 0.53 |
| NPFCs with BC vs control | 1.00 | 0.69 (0.37, 1.27) | 0.93 (0.51, 1.70) | 0.69 (0.37, 1.29) | 0.43 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.94 (0.45, 1.94) | 1.08 (0.54, 2.16) | 0.81 (0.39, 1.66) | 0.69 |
| n–3 PUFAs4 | 0 < n ≤ 7.05 | 7.05 < n ≤ 7.64 | 7.64 < n ≤ 8.36 | 8.36 < n | — |
| NPFCs alone vs control | 1.00 | 0.76 (0.41, 1.41) | 0.72 (0.40, 1.30) | 0.52 (0.28, 0.96) | 0.04 |
| NPFCs with BC vs control | 1.00 | 0.52 (0.28, 0.96) | 0.54 (0.30, 0.98) | 0.49 (0.27, 0.90) | 0.03 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.72 (0.35, 1.47) | 0.63 (0.31, 1.28) | 0.79 (0.39, 1.60) | 0.41 |
| Eicosapentaenoic acid (20:5) | 0 < n ≤ 0.46 | 0.46 < n ≤ 0.56 | 0.56 < n ≤ 0.69 | 0.69 < n | — |
| NPFCs alone vs control | 1.00 | 0.33 (0.18, 0.61) | 0.25 (0.14, 0.47) | 0.33 (0.18, 0.61) | <0.0001 |
| NPFCs with BC vs control | 1.00 | 1.22 (0.70, 2.13) | 0.51 (0.28, 0.94) | 0.33 (0.16, 0.66) | 0.0002 |
| NPFCs with BC vs NPFCs alone | 1.00 | 2.36 (1.21, 4.59) | 2.00 (0.96, 4.16) | 0.75 (0.33, 1.71) | 0.82 |
| Docosapentaenoic acid (22:5) | 0 < n ≤ 1.62 | 1.62 < n ≤ 1.85 | 1.85 < n ≤ 2.09 | 2.09 < n | — |
| NPFCs alone vs control | 1.00 | 0.83 (0.45, 1.54) | 0.91 (0.48, 1.73) | 0.79 (0.42, 1.52) | 0.57 |
| NPFCs with BC vs control | 1.00 | 0.54 (0.29, 1.00) | 0.58 (0.31, 1.08) | 0.37 (0.19, 0.74) | 0.009 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.88 (0.44, 1.77) | 1.01 (0.49, 2.09) | 0.53 (0.25, 1.11) | 0.15 |
| Docosahexaenoic acid (22:6) | 0 < n ≤ 4.40 | 4.40 < n ≤ 4.90 | 4.90 < n ≤ 5.46 | 5.46 < n | — |
| NPFCs alone vs control | 1.00 | 0.94 (0.50, 1.77) | 0.97 (0.53, 1.76) | 0.68 (0.36, 1.25) | 0.24 |
| NPFCs with BC vs control | 1.00 | 0.70 (0.38, 1.30) | 0.67 (0.37, 1.22) | 0.60 (0.33, 1.11) | 0.11 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.72 (0.34, 1.52) | 0.55 (0.27, 1.12) | 0.71 (0.35, 1.46) | 0.26 |
1
PUFAs, polyunsaturated fatty acids. Models stratified by year of interview (1995–1996, 1998–1999, and 2000–2001) and adjusted for age by conditional logistic regression. Number of subjects in age-adjusted model: 155 with NPFCs, 127 with NPFCs and BC, and 1030 controls.
2
Odds ratio and 95% CI (all such values).
3
18:2n–6cc + 18:3n–6 + 20:2n–6 + 20:3n–6 + 20:4n–6 + 22:2n–6 + 22:4n–6.
4
18:3n–3 + 20:3n–3 + 20:5n–3 + 22:5n–3 + 22:6n–3.