TABLE 4.
Erythrocyte fatty acid concentrations among women in Shanghai, China, and risk of proliferative fibrocystic conditions (PFCs) with or without breast cancer (BC)1
| Quartiles of erythrocyte fatty acid concentrations |
||||||
| 1 | 2 | 3 | 4 | P for trend | ||
| % of total by wt | ||||||
| Palmitic acid (16:0) | 0 < n ≤ 18.16 | 18.16 < n ≤ 18.70 | 18.70 < n ≤ 19.27 | 19.27 < n | — | |
| PFCs vs control | 1.00 | 0.94 (0.44, 2.03)2 | 0.67 (0.32, 1.47) | 1.16 (0.55, 2.42) | 0.64 | |
| PFCs with BC vs control | 1.00 | 0.52 (0.21, 1.30) | 0.66 (0.28, 1.52) | 1.19 (0.53, 2.64) | 0.13 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 0.57 (0.23, 1.45) | 0.77 (0.32, 1.87) | 0.87 (0.38, 1.98) | 0.75 | |
| All BCs vs PFCs alone | 1.00 | 0.66 (0.31, 1.41) | 1.02 (0.49, 2.08) | 1.14 (0.58, 2.25) | 0.22 | |
| Palmitoleic acid (16:1n–7) | 0 < n ≤ 0.13 | 0.13 < n ≤ 0.17 | 0.17 < n ≤ 0.24 | 0.24 < n | — | |
| PFCs alone vs control | 1.00 | 1.91 (1.03, 3.55) | 2.87 (1.50, 5.50) | 2.87 (1.42, 5.80) | 0.001 | |
| PFCs with BC vs control | 1.00 | 3.93 (1.63, 9.48) | 8.76 (3.65, 21.0) | 8.13 (3.21, 20.6) | <0.0001 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 2.62 (0.64, 4.12) | 2.55 (1.02, 6.35) | 1.97 (0.74, 5.24) | 0.12 | |
| All BCs vs PFCs alone | 1.00 | 1.09 (0.55, 2.17) | 1.76 (0.90, 3.44) | 1.72 (0.84, 3.53) | 0.04 | |
| Oleic acid (18:1n–9c) | 0 < n ≤ 9.81 | 9.81 < n ≤ 10.38 | 10.38< n ≤ 11.02 | 11.02 < n | — | |
| PFCs alone vs control | 1.00 | 1.01 (0.58, 1.76) | 0.82 (0.46, 1.50) | 1.67 (0.82, 3.42) | 0.46 | |
| PFCs with BC vs control | 1.00 | 1.06 (0.59, 1.89) | 0.69 (0.35, 1.37) | 1.24 (0.60, 2.56) | 0.98 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 1.12 (0.59, 2.11) | 0.86 (0.42, 1.78) | 1.00 (0.46, 2.21) | 0.85 | |
| All BCs vs PFCs alone | 1.00 | 1.01 (0.60, 1.70) | 1.06 (0.60, 1.88) | 0.99 (0.52, 1.90) | 0.94 | |
| Vaccenic acid (18:1n–7) | 0 < n ≤ 0.85 | 0.85 < n ≤ 0.93 | 0.93 < n ≤ 1.01 | 1.01 < n | — | |
| PFCs alone vs control | 1.00 | 1.40 (0.78, 2.48) | 1.22 (0.65, 2.29) | 1.09 (0.56, 2.14) | 0.86 | |
| PFCs with BC vs control | 1.00 | 1.14 (0.61, 2.14) | 1.16 (0.61, 2.20) | 1.09 (0.54, 2.20) | 0.76 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 0.66 (0.33, 1.33) | 0.98 (0.48, 2.00) | 0.87 (0.39, 1.93) | 0.97 | |
| All BCs vs PFCs alone | 1.00 | 0.85 (0.48, 1.52) | 1.32 (0.73, 2.38) | 1.24 (0.65, 2.37) | 0.24 | |
| n−6 PUFAs4 | 0 < n ≤ 26.61 | 26.61 < n ≤ 27.76 | 27.76 < n ≤ 29.48 | 29.48 < n | — | |
| PFCs alone vs control | 1.00 | 0.73 (0.42, 1.28) | 0.66 (0.37, 1.20) | 0.80 (0.40, 1.59) | 0.31 | |
| PFCs with BC vs control | 1.00 | 0.91 (0.49, 1.69) | 1.17 (0.62, 2.19) | 1.35 (0.62, 2.95) | 0.38 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 1.35 (0.67, 2.71) | 2.21 (1.11, 4.44) | 1.99 (0.88, 4.46) | 0.03 | |
| All BCs vs PFCs alone | 1.00 | 1.31 (0.76, 2.25) | 1.51 (0.86, 2.67) | 1.88 (0.99, 3.57) | 0.04 | |
| Linoleic acid (18:2) | 0 < n ≤ 10.19 | 10.19 < n ≤ 11.40 | 11.40 < n ≤ 13.63 | 13.63 < n | ||
| PFCs alone vs control | 1.00 | 0.70 (0.40, 1.24) | 0.60 (0.33, 1.11) | 0.88 (0.43, 1.78) | 0.40 | |
| PFCs with BC vs control | 1.00 | 0.50 (0.27, 0.92) | 0.47 (0.25, 0.91) | 0.73 (0.33, 1.61) | 0.13 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 0.83 (0.43, 1.60) | 0.84 (0.40, 1.76) | 0.92 (0.42, 2.02) | 0.75 | |
| All BCs vs PFCs alone | 1.00 | 1.05 (0.62, 1.80) | 1.04 (0.58, 1.89) | 1.17 (0.62, 2.19) | 0.67 | |
| γ-Linolenic acid (18:3n–6) | 0 < n ≤ 0.05 | 0.05 < n ≤ 0.07 | 0.07 < n ≤ 0.09 | 0.09 < n | — | |
| PFCs alone vs control | 1.00 | 0.68 (0.40, 1.15) | 1.17 (0.59, 2.31) | 1.03 (0.52, 2.04) | 0.72 | |
| PFCs with BC vs control | 1.00 | 1.15 (0.61, 2.16) | 2.57 (1.24, 5.32) | 2.54 (1.19, 5.42) | 0.003 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 1.74 (0.88, 3.42) | 2.28 (1.04, 5.01) | 2.50 (1.13, 5.57) | 0.02 | |
| All BCs vs PFCs alone | 1.00 | 1.32 (0.78, 2.26) | 1.59 (0.85, 3.00) | 2.23 (1.22, 4.07) | 0.008 | |
| Arachidonic acid (20:4) | 0 < n ≤ 11.43 | 11.43 < n ≤ 12.17 | 12.17 < n ≤ 12.92 | 12.92 < n | — | |
| PFCs alone vs control | 1.00 | 0.93 (0.51, 1.68) | 0.77 (0.41, 1.47) | 0.86 (0.45, 1.62) | 0.54 | |
| PFCs with BC vs control | 1.00 | 0.74 (0.36, 1.53) | 1.72 (0.88, 3.38) | 1.11 (0.56, 2.18) | 0.33 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 0.78 (0.36, 1.70) | 1.84 (0.87, 3.88) | 1.41 (0.67, 3.00) | 0.11 | |
| All BCs vs PFCs alone | 1.00 | 0.63 (0.35, 1.13) | 1.35 (0.75, 2.43) | 0.93 (0.51, 1.69) | 0.53 | |
| n−3 PUFAs5 | 0 < n ≤ 7.05 | 7.05 < n ≤ 7.64 | 7.64 < n ≤ 8.36 | 8.36 < n | — | |
| PFCs alone vs control | 1.00 | 0.61 (0.31, 1.20) | 0.92 (0.49, 1.72) | 1.04 (0.57, 1.92) | 0.57 | |
| PFCs with BC vs control | 1.00 | 0.73 (0.36, 1.46) | 0.83 (0.43, 1.59) | 0.61 (0.31, 1.20) | 0.22 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 1.51 (0.70, 3.26) | 1.19 (0.59, 2.42) | 0.76 (0.37, 1.59) | 0.37 | |
| All BCs vs PFCs alone | 1.00 | 1.01 (0.55, 1.87) | 0.84 (0.47, 1.48) | 0.57 (0.32, 1.00) | 0.04 | |
| Eicosapentaenoic acid (20:5) | 0 < n ≤ 0.46 | 0.46 < n ≤ 0.56 | 0.56 < n ≤ 0.69 | 0.69 < n | — | |
| PFCs alone vs control | 1.00 | 0.74 (0.90, 0.47) | 1.23 (0.68, 2.21) | 0.93 (0.50, 1.74) | 0.91 | |
| PFCs with BC vs control | 1.00 | 1.29 (0.68, 2.43) | 0.74 (0.39, 1.42) | 0.79 (0.40, 1.55) | 0.25 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 1.32 (0.65, 2.67) | 0.50 (0.24, 1.05) | 0.78 (0.37, 1.65) | 0.15 | |
| All BCs vs PFCs alone | 1.00 | 1.15 (0.65, 2.04) | 0.48 (0.27, 0.85) | 0.51 (0.27, 0.94) | 0.003 | |
| Docosapentaenoic acid (22:5) | 0 < n ≤ 1.62 | 1.62 < n ≤ 1.85 | 1.85 < n ≤ 2.09 | 2.09 < n | — | |
| PFCs alone vs control | 1.00 | 0.86 (0.45, 1.63) | 0.99 (0.51, 1.93) | 1.00 (0.50, 1.98) | 0.87 | |
| PFCs with BC vs control | 1.00 | 0.63 (0.30, 1.30) | 1.05 (0.51, 2.15) | 0.57 (0.27, 1.23) | 0.35 | |
| PFCs with BC vs PFC alone3 | 1.00 | 0.65 (0.31, 1.38) | 1.01 (0.49, 2.10) | 0.79 (0.37, 1.71) | 0.88 | |
| All BCs vs PFCs alone | 1.00 | 0.65 (0.36, 1.17) | 0.87 (0.48, 1.57) | 0.57 (0.30, 1.08) | 0.20 | |
| Docosahexaenoic acid (22:6) | 0 < n ≤ 4.40 | 4.40 < n ≤ 4.90 | 4.90 < n ≤ 5.46 | 5.46 < n | — | |
| PFCs alone vs control | 1.00 | 0.82 (0.41, 1.63) | 0.77 (0.40, 1.49) | 1.33 (0.72, 2.45) | 0.29 | |
| % of total by wt | ||||||
| PFCs with BC vs control | 1.00 | 0.80 (0.40, 1.58) | 0.68 (0.35, 1.32) | 0.81 (0.43, 1.53) | 0.47 | |
| PFCs with BC vs PFCs alone3 | 1.00 | 1.05 (0.48, 2.31) | 0.96 (0.46, 2.04) | 0.72 (0.35, 1.48) | 0.32 | |
| All BCs vs PFCs alone | 1.00 | 0.86 (0.46, 1.63) | 0.84 (0.46, 1.54) | 0.58 (0.33, 1.01) | 0.06 | |
1
PUFAs, polyunsaturated fatty acids. Models were stratified by year of interview (1995–1996, 1998–1999, and 2000–2001) and adjusted for age by conditional logistic regression analysis. Number of subjects in age-adjusted model: 185 with PFCs, 114 with NPFCs and BC, and 1030 control subjects.
2
Odds ratio and 95% CI (all such values).
3
Adjusted for age and number of induced abortions, stratified by year of interview.
4
18:2n–6cc + 18:3n–6 + 20:2n–6 + 20:3n–6 + 20:4n–6 + 22:2n–6 + 22:4n–6.
5
18:3n–3 + 20:3n–3 + 20:5n–3 + 22:5n–3 + 22:6n–3.