TABLE 5.
Ratios of erythrocyte fatty acid concentrations among women in Shanghai, China, and risk of nonproliferative fibrocystic conditions (NPFCs) and proliferative fibrocystic conditions (PFCs) with or without breast cancer (BC)1
| Quartiles of erythrocyte fatty acid concentrations |
|||||
| 1 | 2 | 3 | 4 | P for trend | |
| % of total by wt | |||||
| n–7 Saturation index (16:0/16:1n–7) | |||||
| Erythrocyte fatty acid cutoffs | 0 < n ≤ 77.8 | 77.8 < n ≤ 112.3 | 112.3 < n ≤ 141.5 | 141.5 < n | |
| NPFCs alone vs control | 1.00 | 1.44 (0.77, 2.72)2 | 0.59 (0.29, 12177) | 0.49 (0.25, 0.97) | 0.002 |
| NPFCs with BC vs control | 1.00 | 1.12 (0.63, 2.02) | 0.35 (0.18, 0.70) | 0.21 (0.10, 0.44) | <0.0001 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.69 (0.35, 1.37) | 0.52 (0.24, 1.13) | 0.44 (0.19, 1.00) | 0.03 |
| PFCs alone vs control | 1.00 | 1.06 (0.55, 2.03) | 0.68 (0.35, 1.34) | 0.33 (0.17, 0.67) | 0.0004 |
| PFCs with BC vs control | 1.00 | 1.13 (0.59, 2.15) | 0.48 (0.23, 0.99) | 0.11 (0.04, 0.27) | <0.0001 |
| PFCs with BC vs PFCs alone3 | 1.00 | 1.22 (0.62, 2.39) | 0.86 (0.42, 1.79) | 0.47 (0.19, 1.20) | 0.10 |
| All BCs vs PFCs alone | 1.00 | 0.96 (0.55, 1.67) | 0.62 (0.34, 1.12) | 0.52 (0.26, 1.04) | 0.02 |
| Total n–3:n–6 PUFA4 | |||||
| Erythrocyte fatty acid cutoffs | 0 < n ≤ 0.24 | 0.24 < n ≤ 0.27 | 0.27 < n ≤ 0.31 | 0.31 < n | |
| NPFCs alone vs control | 1.00 | 1.16 (0.61, 2.20) | 0.83 (0.44, 1.54) | 0.68 (0.35, 1.29) | 0.12 |
| NPFCs with BC vs control | 1.00 | 0.92 (0.48, 1.76) | 0.73 (0.40, 1.33) | 0.63 (0.33, 1.20) | 0.12 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.76 (0.36, 1.58) | 0.81 (0.40, 1.67) | 0.75 (0.35, 1.59) | 0.52 |
| PFCs alone vs control | 1.00 | 1.63 (0.80, 3.32) | 1.18 (0.60, 2.32) | 1.80 (0.93, 3.50) | 0.17 |
| PFCs with BC vs control | 1.00 | 1.29 (0.60, 2.67) | 1.23 (0.62, 2.41) | 0.78 (0.38, 1.61) | 0.45 |
| PFCs with BC vs PFCs alone3 | 1.00 | 0.70 (0.31, 1.58) | 0.98 (0.46, 2.08) | 0.45 (0.20, 0.99) | 0.09 |
| All BCs vs PFCs alone | 1.00 | 0.61 (0.32, 1.17) | 0.75 (0.40, 1.39) | 0.38 (0.20, 0.71) | 0.006 |
| Linoleic acid:γ-linolenic acid | |||||
| Erythrocyte fatty acid cutoffs | 0 < n ≤ 128.6 | 128.6 < n ≤ 173.0 | 173.0 < n ≤ 229.2 | 229.2 < n | |
| NPFCs alone vs control | 1.00 | 0.65 (0.32, 1.34) | 0.96 (0.50, 1.87) | 1.02 (0.53, 1.97) | 0.54 |
| NPFCs with BC vs control | 1.00 | 0.86 (0.47, 1.58) | 0.40 (0.21, 0.78) | 0.60 (0.32, 1.12) | 0.03 |
| NPFCs with BC vs NPFCs alone | 1.00 | 0.76 (0.36, 1.58) | 0.81 (0.40, 1.67) | 0.75 (0.35, 1.59) | 0.52 |
| PFCs alone vs control | 1.00 | 0.83 (0.38, 1.81) | 0.30 (0.14, 0.67) | 0.42 (0.20, 0.87) | 0.004 |
| PFCs with BC vs control | 1.00 | 0.70 (0.36, 1.36) | 0.34 (0.17, 0.68) | 0.34 (0.17, 0.70) | <0.001 |
| PFCs with BC vs PFCs alone3 | 1.00 | 0.71 (0.34, 1.48) | 0.58 (0.27, 1.25) | 0.42 (0.20, 0.89) | 0.02 |
| All BCs vs PFCs alone | 1.00 | 0.74 (0.41, 1.34) | 0.54 (0.29, 1.00) | 0.51 (0.28, 0.90) | 0.01 |
| γ-Linolenic acid:arachidonic acid | |||||
| Erythrocyte fatty acid cutoffs | 0 < n ≤ 0.004 | 0.004 < n ≤ 0.006 | 0.006 < n ≤ 0.008 | 0.008 < n | |
| NPFCs alone vs control | 1.00 | 0.74 (0.43, 1.28) | 0.79 (0.43, 1.44) | 1.00 (0.51, 1.96) | 0.83 |
| NPFCs with BC vs control | 1.00 | 1.07 (0.59, 1.94) | 1.18 (0.63, 2.21) | 1.68 (0.86, 3.28) | 0.15 |
| NPFCs with BC vs NPFCs alone | 1.00 | 1.30 (0.67, 2.56) | 1.48 (0.72, 3.05) | 2.14 (1.01, 4.53) | 0.05 |
| PFCs alone vs control | 1.00 | 0.88 (0.50, 1.54) | 1.21 (0.66, 2.23) | 1.01 (0.49, 2.09) | 0.70 |
| PFCs with BC vs control | 1.00 | 1.17 (0.62, 2.21) | 1.47 (0.75, 2.90) | 2.20 (1.02, 4.72) | 0.04 |
| PFCs with BC vs PFCs alone3 | 1.00 | 1.20 (0.61, 2.39) | 1.42 (0.68, 2.95) | 1.95 (0.87, 4.38) | 0.10 |
| All BCs vs PFCs alone | 1.00 | 1.08 (0.62, 1.88) | 1.15 (0.64, 2.05) | 2.08 (1.10, 3.91) | 0.04 |
1
Models were stratified by year of interview (1995–1996, 1998–1999, and 2000–2001) and adjusted for age by conditional logistic regression. Number of subjects in age-adjusted model: 185 with PFCs, 114 with NPFCs and BC, and 1030 control subjects.
2
Odds ratio and 95% CI (all such values).
3
Adjusted for age and number of induced abortions, stratified by year of interview.
4
Ratio of n–3 to n–6 polyunsaturated fatty acids.