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Effect of LAU-0901 on local cerebral blood flow (LCBF). Basal indicated no MCAo. LAU-0901 (30 mg/kg; n=11) or vehicle (n=8) was administered IP at 1 h after onset of reperfusion. LCBF was reduced to 15% during MCAo in all animals and increased to 41% from baseline in vehicle-treated mice. In contrast, treatment with LAU-0901 increased LCBF to 77% at 6 h compared to vehicle-treated mice. Values shown are means ± SEM. *Significantly different from corresponding vehicle group (p <0.05).
