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. Author manuscript; available in PMC: 2009 Jun 13.
Published in final edited form as: Biochem Biophys Res Commun. 2008 Apr 8;370(4):613–618. doi: 10.1016/j.bbrc.2008.03.147

Fig. 3.

Fig. 3

Design and activity of minimal hypoxia-inducible enhancers. The effect of arrangement of three HBSs (A), increasing number of HBSs in par arrangement (B), cotransfection of HIF-1α(P402A, P564A) and HIF-2α(P405A, P531A) mutants (C) on reporter activity. Transfection and expression of promoter activities were as described in Fig. 1. Production of HIF-1α(P402A, P564A) and HIF-2α(P405A, P531A) mutants was evaluated by Western blotting (D).

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