Table 1.

Single SNP association results generated in four independent Alzheimer Disease datasets (supplemental Table 3 shows allele and genotype frequencies). Nominally significant p-values are in bold; the alleles putatively associated with AD are depicted only for SNPs generating nominal p-values< 0.05. N/D = not done.

				Case-Control datasets					Familial datasets
				North European			Canadian		North European	Caribbean Hispanic
Gene (Locus)	Distance (kb)	SNP	SNP Function	p-values		Putative risk allele	P-values		FBAT p-values
				genotype	Allele		genotype	Allele
PLG (6q26)		rs3757019	intron 5	0.62	0.34		N/D	N/D	N/D	N/D
	4.4	rs1130656	exon 8 F314F	0.21	0.18		N/D	N/D	N/D	N/D
	34.5	rs11060	exon 19 G762G	0.76	0.5		N/D	N/D	N/D	N/D
PAI-1 (7q22)		rs1799889	5′ UTR -675 4G/5G	0.002 0.008*	0.0003 0.001*	4G	0.24	0.54	0.49	0.46
	4.8	rs2227662	intron 2	0.36	0.92		N/D	N/D	N/D	N/D
	4.7	rs2227692	intron 6	0.86	0.63		N/D	N/D	N/D	N/D
	1.8	rs11178	3′ UTR	0.46	0.27		N/D	N/D	N/D	N/D
PLAT (8p12)		rs2020923	intron 10	0.26	0.16		N/D	N/D	N/D	N/D
	2.3	Alu I/D	intron 7	0.0001 0.0004*	0.00003 0.0001*	D	0.83	0.74	0.28	0.15
	5.5	rs1058720	exon 5 D167D	0.006 0.02*	0.01 0.05*	C	0.09	0.17	0.48	0.93
	1	rs2070711	intron 3	0.54	0.35		N/D	N/D	N/D	N/D
PLI (17p13)		rs2287322	5′ UTR	0.002 0.009*	0.0003 0.001*	G	0.87	0.79	0.42	0.86
	15.2	rs736060	intron 8	0.86	0.81		N/D	N/D	N/D	N/D
	1.4	rs1057335	exon 9 K434R	0.06	0.02 0.06		N/D	N/D	N/D	N/D

^*Association of SNP with AD is significant after adjustment for multiple testing with Bonferroni correction.