Figure 2. Selected human protein families with alpha-rod repeats.

The cartoon summarizes the findings for seven human proteins. The green ellipses represent regions of alpha-rod repeats as deduced by a combination of our method, analysis of homologs, and iterative sequence analysis. Further details for each case, including an overview of repeat predictions and regions with amino acid bias overlaid to the multiple sequence alignment of the family using an update of the BiasViz software [71] are available as supplementary Figure S3 in Text S1.