TABLE 1.

Scope and question hierarchy relating to vitamin B-12 fortification

Is there enough information about vitamin B-12 fortification to make an informed decision (recommendation)?

If “yes” (sufficient information):

Do benefits outweigh risks? Then fortify.

Do risks outweigh benefits? Then do not fortify.

If “no” (insufficient information):

What research questions need to be addressed before revisiting the question?

If the decision is to fortify

How much vitamin B-12 should be used?

What should the food vehicle be?

What are the stability considerations?

What monitors should be put in place?

If the decision is to not fortify

What additional information is required before reconsidering the question?