TABLE 3.

Hazard ratios (HRs) and 95% CIs for pancreatic cancer based on baseline serum α-tocopherol by polyunsaturated fat intake in male smokers¹

			HR (95% CI)
	No. of cases	Person-years	Joint effect	Stratified effect	P for trend	P for interaction
High polyunsaturated fat intake, >9.9 g/d
Quintile of serum α-tocopherol
<9.4 mg/L	30	22,332	1.00 (reference)	1.00 (reference)		0.05
≥9.4 to <10.8 mg/L	26	32,278	0.59 (0.35, 1.00)	0.61 (0.36, 1.04)
≥10.8 to <12.2 mg/L	22	38,889	0.40 (0.23, 0.70)	0.42 (0.24, 0.75)
≥12.2 to <14.2 mg/L	47	43,775	0.71 (0.43, 1.16)	0.78 (0.46, 1.32)
≥14.2 mg/L	28	51,599	0.32 (0.18, 0.58)	0.38 (0.20, 0.73)
Continuous HR2	153	188,877	—	0.86 (0.75, 0.97)	0.02	0.02
Low polyunsaturated fat intake, ≤9.9 g/d
Quintile of serum α-tocopherol
<9.4 mg/L	47	46,799	0.70 (0.44, 1.12)	1.00 (reference)
≥9.4 to <10.8 mg/L	31	42,334	0.49 (0.29, 0.82)	0.66 (0.42, 1.06)
≥10.8 to <12.2 mg/L	21	27,208	0.36 (0.20, 0.64)	0.47 (0.27, 0.81)
≥12.2 to <14.2 mg/L	30	32,100	0.57 (0.32, 1.00)	0.72 (0.42, 1.24)
≥14.2 mg/L	24	23,906	0.57 (0.31, 1.08)	0.69 (0.37, 1.29)
Continuous HR2	153	182,347	—	0.97 (0.85, 1.10)	0.64

¹Stratified analysis is based on median split cutoffs of energy-adjusted polyunsaturated fat intake. HRs were adjusted for age at randomization, serum cholesterol, smoking history (years smoked and cigarettes smoked per day), history of diabetes mellitus, and energy intake (27,074 subjects with complete serum and dietary data; n = 306 cases). P for interaction = 0.05 for categorical stratified analysis.

²Continuous variables were standardized to the average size of the 2 central quartiles. Therefore, this is the HR associated with a 25% change in serum concentrations relative to the cohort distribution. P for interaction = 0.02. The P for trend is based on the P value of the continuous risk estimate.