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. 2009 Feb 5;28(6):686–696. doi: 10.1038/emboj.2009.23

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Copyright © 2009, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation or the creation of derivative works without specific permission.

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Aberrant Snail1 activation impairs calcein apposition. (A, B) Mineral apposition was visualised after calcein injection (n=5 per group). (C–E) Snail1 activation increases the transcription of the early differentiation osteoblast markers Type I Collagen and alkaline phosphatase (Alp; only a slight increase) and decreases that of the differentiated population marker Osteocalcin. Real-time PCR was carried out on limbs obtained from 16-week-old Snail1-ER mice after 8 weeks of treatment with tamoxifen. The results are expressed as mean±s.d. from three independent experiments. (F, G) The number of osteoblasts per bone perimeter is unaltered on Snail1 activation. Histomorphometric analysis of bones from 16-week-old wild-type and Snail1-ER mice (n=10). Ob.S., osteoblast surface; Ob.N., osteoblast number; B.S., bone surface; B.Pm., bone perimeter. ANOVA analysis, ^*P<0.1 and ^**P<0.01.