Table 3.

Next-Day Residual Measures

	Baseline	Week 1	Month 1	Month 3	Month 5	Month 6	Placebo Run-out
Morning alertness
Placebo	4.09	3.88	3.90	3.75	3.80	3.70	3.67
Ramelteon	4.12	4.00	3.86	3.79	3.79	3.78	3.67
Ability to concentrate
Placebo	4.10	3.89	3.96	3.79	3.85	3.75	3.67
Ramelteon	4.15	3.95	3.83	3.73	3.77	3.79	3.67
DSST
Placebo	36.00	38.31	40.51	38.36	40.27	41.72	41.49
Ramelteon	35.27	38.08	40.48	39.29	40.77	41.53	42.27
Immediate memory recall
Placebo	6.78	8.13	7.60	8.98	8.81	8.46	8.43
Ramelteon	6.89	8.11	7.50	9.12	8.67	8.36	8.09
Delayed memory recall
Placebo	4.87	6.44	6.30	7.79	7.45	7.42	6.95
Ramelteon	5.04	6.41	6.32	7.92	7.46	7.24	6.52
VAS for feelings – energetic/fatigued
Placebo	47.99	42.53	41.77	40.72	39.08	39.22	38.14
Ramelteon	47.83	44.67	42.66	39.45	40.93	43.26a	42.22a
VAS for mood - drowsy
Placebo	36.06	31.11	30.22	29.61	30.62	28.65	27.76
Ramelteon	35.22	34.46a	31.96	29.69	30.24	30.69	28.86
VAS for mood – slowed down
Placebo	34.43	30.12	28.87	29.11	29.28	28.11	26.25
Ramelteon	33.85	33.27a	30.87	28.78	29.88	30.41	28.42
VAS for mood - sleepy
Placebo	37.86	33.17	31.78	30.41	31.23	30.12	28.62
Ramelteon	37.68	36.42a	33.08	31.12	31.58	31.94	29.48
VAS for feelings – thinking slowed down/speeded up
Placebo	39.08	39.91	38.88	39.25	39.28	40.90	40.79
Ramelteon	39.31	38.39	40.59	40.58	39.46	37.34a	37.94

Data are reported as least-square mean. The number of subjects was 224 in the Placebo group and 227 in the Ramelteon group. The number for each time point may be slightly less in either group due to available data. DSST refers to Digit Symbol Substitution Test.

Subjective morning alertness and ability to concentrate are evaluated on a 7-point scale in which 1 = excellent and 7 = extremely poor. Visual analog scale (VAS) for Feelings: 0 = energetic, 100 = fatigued; VAS for Mood: 0 = a little, 100 = a lot;

^aP < 0.05 vs placebo (obtained using t-tests from the analysis of covariance model of the overall treatment comparison).