Table 2.
Antiplasmodial activity of CQ-derived amides against HB3 and Dd2
| Strain/IC50 (nM)a | |||
|---|---|---|---|
| Compound # | HB3 | Dd2 | RIb |
| CQ | 10 | 127 | 12.7 |
| 27 | 32 | 760 | 24.1 |
| 28 | 23 | 559 | 24.4 |
| 29 | 29 | >1000 | - |
| 30 | 16 | 672 | 41.2 |
| 31 | 28 | 385 | 12.9 |
| 32 | >1000 | >1000 | - |
| 33 | >1000 | 305 | - |
| 34 | >1000 | >1000 | - |
| 35 | >1000 | >1000 | - |
| 36 | >1000 | >1000 | - |
| 37 | 500 | 764 | 1.5 |
| 38 | 479 | >1000 | - |
| 39 | 902 | >1000 | - |
| 40 | >1000 | >1000 | - |
| 41 | >1000 | >1000 | - |
| 42 | >1000 | >1000 | - |
| 43 | 449 | 792 | 1.8 |
| 44 | 756 | >1000 | - |
| 45 | 179 | 651 | 3.6 |
a
IC50 values were obtained from an average of two separate determinations each in triplicate.
b
Resistance Index (CQR-IC50/CQS-IC50).