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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Bioorg Med Chem. 2008 Nov 12;17(1):270–283. doi: 10.1016/j.bmc.2008.11.009

Table 3.

Antiplasmodial activity of fluorinated CQ-derived amides 46-54

Strain/IC50 (nM)a
Compound HB3 Dd2 RIb
CQ 10 127 12.7
46 80 199 2.5
47 145 236 1.6
48 276 510 1.9
49 234 277 1.2
50 166 197 1.2
51 97 137 1.4
52 118 314 2.7
53 180 556 3.1
54 72 87 1.2
a

IC50 values are an average of two separate determinations each done in triplicate.

b

Resistance Index (IC50 CQR)/(IC50 CQS)