Table 1.
Hrs UIM-interacting proteins identified from the IVEC screen
| Gene | Protein Name (Alternate name) | Accession Number |
|---|---|---|
| Membrane proteins | ||
| APPa | amyloid beta (A4) protein | NP_958816 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | NP_001633 |
| ATP1A1 | Na+/K+ ATPase alpha 1 subunit | NP_000692 |
| ATP2A2 | ATPase, Ca2+ transporting, slow twitch 2 | NP_001672 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein | NP_055976 |
| BSG | basigin | NP_940991 |
| C3orf1 | hypothetical protein LOC51300 | NP_057673 |
| FAM5C | family with sequence similarity 5, member C | NP_950252 |
| MEST | mesoderm specific transcript | NP_002393 |
| TMCC2 | transmembrane and coiled-coil domain family 2 | NP_055673 |
| TMEM49 | transmembrane protein 49 (VMP1) | NP_112200 |
| UNC84B | unc-84 homolog B (Rab5IP) | NP_056189 |
| Membrane protein-associated adaptor proteins | ||
| AHCYL1 | s-adenosylhomocysteine hydrolase-like 1(IRBIT) | NP_006612 |
| CASKc | calcium/calmodulin-dependent serine protein kinase | NP_003679 |
| TJP2 | tight junction protein 2 (ZO-2) | NP_963923 |
| TRAP1 | TNF receptor-associated protein 1 | NP_057376 |
| Vesicular trafficking | ||
| GGA2b | ADP-ribosylation factor binding protein 2 | NP_055859 |
| HSPA8a | heat shock 70 kDa protein 8 (Hsc70) | NP_006588 |
| MAP3K10c | mitogen-activated protein kinase 10 (MLK2) | NP_002437 |
| STXBP1 | syntaxin binding protein 1(Munc18-1) | NP_003156 |
| SCRN1 | secernin 1 | NP_055581 |
| Cytoskeleton and cytoskeleton-dependent transport | ||
| CRMP1 | collapsin response mediator protein 1 | NP_001304 |
| DCTN2 | dynactin 2 (dynamitin) | NP_006391 |
| GFAPa | glial fibrillary acidic protein | NP_002046 |
| MARK4a | MAP/microtubule affinity-regulating kinase 4 | NP_113605 |
| PPP1R16A | protein phosphatase 1, regulator (inhibitor) subunit 16A (MYPT3) | NP_116291 |
| RHOBTB3 | rho-related BTB domain containing 3 | NP_055714 |
| TUBBa | tubulin, beta | NP_821133 |
| TUBB2A | tubulin, beta 2 | NP_001060 |
| Cell signaling | ||
| ESRRG | estrogen-related receptor gamma (ERR3) | NP_996317 |
| ILKAP | integrin-linked kinase-associated protein phosphatase 2C | NP_789769 |
| PPP1R7 | protein phosphatase 1 regulatory subunit 7 | NP_002703 |
| RSU1 | ras suppressor protein 1 | NP_036557 |
| UBA1 | ubiquitin-activating enzyme E1 | NP_003325 |
| Metabolism | ||
| ACLY | ATP citrate lyase | NP_942127 |
| CBS | cystathionine-beta-synthase | NP_000062 |
| DECR | 2,4-dienoyl CoA reductase 1 | NP_001350 |
| MAT2A | methionine adenosyltransferase II alpha | NP_005902 |
| MTHFD1L | C1 tetrahydrofolate synthase | NP_056255 |
| OSBPL5 | oxysterol-binding protein-like protein 5 | NP_065947 |
| PLD3 | phospholipase D family, member 3 | NP_036400 |
| PFKM | phosphofructokinase, muscle | NP_000280 |
| Ribonucleoprotein granules | ||
| HNRPDL | heterogeneous nuclear ribonucleoprotein D-like | NP_112740 |
| RPS3A | ribosomal protein S3a | NP_000997 |
| SF3B3 | splicing factor 3b, subunit 3 | NP_036558 |
| Novel proteins | ||
| LOC349114 | hypothetical protein LOC349114 | Q8N836 |
| PTCD3 | Pentatricopeptide repeat domain 3 | NP_060422 |
| ZNF302 | zinc finger protein 302 | NP_060913 |
a
known to be ubiquitinated
b
thought to be ubiquitinated based on similarity
c
interacts with an E2 or E3, but is not known to be ubiquitinated