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. 2009 Feb 6;5(2):e1000291. doi: 10.1371/journal.ppat.1000291

Figure 3. Global gene expression profiles of HCV (H77c 1a)-infected mice.

Figure 3

Two-dimensional hierarchical clustering was performed using Resolver System software with an agglomerative algorithm, complete link heuristic criteria, and Euclidian correlation metric. Each column represents gene expression data from an individual experiment (either individual HCV-infected mouse or individual liver sample) and the cluster represents genes that showed a >2-fold change (P value<0.05) in at least 1 experiment. Genes shown in red were up-regulated; genes shown in green down-regulated and genes in black indicate no change in expression in HCV-infected tissue relative to a pool (3 individual animals) of donor-matched uninfected tissue. Animal 990 was infected with H77c (+) serum. Animal 975 received 100 µg of H77c RNA by intrahepatic injection while animal 986 received 100 µg of H77c RNA containing the GDD-AAA mutation in the NS5B coding region.