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. 2009 Feb 6;5(2):e1000291. doi: 10.1371/journal.ppat.1000291

Figure 4. Expression of IFN-inducible and lipid metabolism genes in human liver tissue from HCV-infected mice.

Figure 4

The gene sets were IFN-inducible (A), or involved in lipid metabolism (B). Two-dimensional hierarchical clustering was performed using Resolver System software with an agglomerative algorithm, complete link heuristic criteria, and Euclidean correlation metric. Each column represents gene expression data from an individual experiment (either individual HCV-infected mouse or individual liver sample). Genes were selected as at least 2-fold regulated (P value<0.05) in at least 1 experiment. Genes shown in red are up-regulated and genes shown in green are down-regulated in HCV-infected tissue relative to donor-matched uninfected tissue, while black indicates no change in gene expression. Animal 990 was infected with H77c (+) serum. Animal 975 H77c RNA by intrahepatic injection while animal 986 received H77c RNA containing the GDD-AAA mutation in the NS5B coding region.