Brain coronal T1-weighted MRI from patients with different clinical presentations of frontotemporal lobar degeneration. (A) BvFTD in a 62-year-old man, MMSE score 24. (B) SD in a 66-year-old man, MMSE 26. (C) PNFA in a 66-year-old woman, MMSE 28. Note the bilateral gray matter loss in the inferior frontal gyrus (arrow), superior frontal gyrus (dashed arrow), the insula (dotted arrow), and the anterior cingulate (arrowhead) in (A) the patient with bvFTD; the atrophy of the left temporal lobe (arrow) in (B) the patient with SD; and the prominent atrophy in the left perisylvian region (arrow) in (C) the patient with PNFA. MRI, magnetic resonance imaging; bvFTD, behavioral variant frontotemporal dementia; MMSE, Mini Mental Status Exam; SD, semantic dementia; PNFA, progressive nonfluent aphasia.