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Transmission electron micrograph of high-pressure frozen and cryosubstituted Verrucomicrobium spinosum. Cell prepared by high-pressure freezing and cryosubstitution showing prostheca (PT), ribosome-free paryphoplasm (P), and an intracytoplasmic membrane (ICM) enclosing a pirellulosome region containing a condensed fibrillar nucleoid (N). Membrane-bounded vesicle-like compartments within some prosthecae extensions are also present (see arrowheads). Bar – 1 μm
