Table 1.
Clinicopathological characteristics and tumor biomarker score according to microsatellite status.
| MSI* n = 43 |
MSS* n = 268 |
P | |||
|---|---|---|---|---|---|
| No. | (%) | No. | (%) | ||
| Gender | |||||
| Male | 21 | (49) | 138 | (51) | 0.9 |
| Female | 22 | (51) | 130 | (49) | |
| Age | |||||
| <70 | 28 | (65) | 217 | (81) | 0.02 |
| ≥70 | 15 | (35) | 51 | (19) | |
| Tumor site | |||||
| Proximal colon | 36 | (84) | 68 | (25) | 0.001 |
| Distal colon | 6 | (14) | 145 | (54) | |
| Rectum | 1 | (2) | 55 | (21) | |
| Stage | |||||
| II | 6 | (14) | 26 | (10) | 0.4 |
| III | 34 | (79) | 210 | (78) | |
| IV | 3 | (7) | 32 | (12) | |
| Differentiation grade (WHO) | |||||
| Well | 5 | (12) | 88 | (33) | 0.001 |
| Intermediate | 7 | (16) | 121 | (45) | |
| Poor | 31 | (72) | 59 | (22) | |
| Perineural tumor invasion | |||||
| + | 5 | (12) | 53 | (20) | 0.5 |
| - | 19 | (44) | 137 | (51) | |
| not assessed | 19 | (44) | 78 | (29) | |
| Vascular tumor invasion | |||||
| V0 | 18 | (42) | 142 | (53) | 0.8 |
| V1 | 8 | (19) | 58 | (22) | |
| Vx | 17 | (39) | 68 | (25) | |
| Intestinal perforation at resection | |||||
| yes | 2 | (5) | 29 | (11) | 0.2 |
| no | 41 | (95) | 239 | (89) | |
| Bowel obstruction before resection | |||||
| yes | 1 | (2) | 44 | (16) | 0.01 |
| no | 42 | (98) | 224 | (84) | |
| Thymidylate synthase level | |||||
| Low | 12 | (28) | 218 | (81) | 0.001 |
| High | 30 | (70) | 47 | (18) | |
| not assessed | 1 | (2) | 3 | (1) | |
| Dihydropyrimidine dehydrogenase level | |||||
| Low | 21 | (49) | 163 | (61) | 0.1 |
| High | 21 | (49) | 97 | (36) | |
| not assessed | 1 | (2) | 8 | (3) | |
*instable (MSI) or stable (MSS) microsatellites