TABLE 1.

BACTERIAL CLEARANCE AND NEUTROPHIL COUNTS IN RATS WITH S. pneumoniae AND E. coli PNEUMONIAS

	S. pneumoniae		E. coli
Duration of Infection (h)	Bacteria Recovered (%)*	Neutrophil Count†	Bacteria Recovered (%)*	Neutrophil Count†
None	0	0.8 ± 0.1	0	0.8 ± 0.1
2	372 ± 133	1.6 ± 0.3‡	120 ± 11	1.7 ± 0.1‡
4	956 ± 704	2.4 ± 0.4‡	428 ± 113	2.3 ± 0.4‡
6	374 ± 288	3.2 ± 0.7‡	763 ± 261	0.8 ± 0.1§
8	73 ± 26	3.7 ± 0.6‡	1,933 ± 1,215§	0.6 ± 0.1§
10	23 ± 7	2.4 ± 0.3‡	21 ± 15	1.6 ± 0.5

n = 5 for all groups except the 10-h studies, in which n = 2.

^*Serial dilutions of the bacterial instillate and lung homogenates were plated on blood agar plates, and colony-forming units were counted and compared. Data are expressed as the percentage of bacterial instillate present in the lungs at each time point.

^†Number of neutrophils present in blood obtained from the inferior vena cava at the end of the study. Data are expressed as the number of neutrophils × 10⁶ per milliliter of blood.

^‡Significantly different from the value in rats that did not receive an infection, p < 0.05.

^§Significantly different from the value in S. pneumoniae at the same time point, p < 0.05.