TABLE 2.
UNIVARIATE SURVIVAL MODELS EXPLORING SERIAL CHANGES IN WALK DISTANCE, DESATURATION AREA, FVC, AND DLCO WHEN ADJUSTING FOR BASELINE VALUES
| n | Hazard Ratio (95% CI) | p Value | |
|---|---|---|---|
| Patients with baseline SaO2 > 88% | |||
| Baseline walk distance | 68 | 0.89 (0.78–1.02) | 0.094 |
| Decrease in WD > 200 ft | 17 | 4.81 (1.75–13.19) | 0.002 |
| Increase in WD or decrease < 200 ft | 51 | 1.00 | REF |
| Baseline DA, 10 U | 70 | 1.73 (1.17–2.54) | 0.006 |
| DA relative change | 70 | 3.47 (1.667.25) | 0.001 |
| Baseline FVC, % predicted | 86 | 0.41 (0.04–3.83) | 0.435 |
| Decrease in FVC (% predicted) relative change > 10% | 20 | 3.57 (1.57–8.10) | 0.002 |
| Increase in FVC (% predicted) relative change or decrease < 10% | 66 | 1.00 | REF |
| Baseline DlCO, % predicted | 70 | 0.19 (0.01–2.90) | 0.233 |
| Decrease in DlCO (% predicted) relative change > 15% | 10 | 3.73 (1.44–9.65) | 0.007 |
| Increase in DlCO (% predicted) relative change or decrease < 15% | 60 | 1.00 | REF |
| Patients with baseline SaO2 ⩽ 88% | |||
| Baseline walk distance | 48 | 0.95 (0.84–1.08) | 0.443 |
| Decrease in WD > 200 ft | 16 | 2.25 (0.85–5.95) | 0.103 |
| Increase in WD or decrease < 200 ft | 32 | 1.00 | REF |
| Baseline DA, 10 U | 57 | 0.83 (0.43–1.60) | 0.583 |
| DA relative change | 57 | 0.53 (0.06–4.78) | 0.590 |
| Baseline FVC, % predicted | 74 | 0.54 (0.07–4.38) | 0.564 |
| Decrease in FVC (% predicted) relative change > 10% | 18 | 1.66 (0.76–3.64) | 0.208 |
| Increase in FVC (% predicted) relative change or decrease < 10% | 56 | 1.00 | REF |
| Baseline DlCO, % predicted | 61 | 0.32 (0.01–10.05) | 0.514 |
| Decrease in DlCO (% predicted) relative change > 15% | 14 | 3.23 (1.41–7.37) | 0.006 |
| Increase in DlCO (% predicted) relative change or decrease < 15% | 47 | 1.00 | REF |
Definition of abbreviations: CI = confidence interval; DA = desaturation area; REF = reference group; WD = walk distance.