TABLE 3.
MULTIVARIATE COX SURVIVAL MODELS EXPLORING THE PAIRWISE PREDICTIVE VALUE OF SERIAL CHANGES IN WALK DISTANCE, DESATURATION AREA, FVC, AND DLCO IN PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS AND AN SaO2 > 88% THROUGHOUT A BASELINE 6-MIN-WALK TEST
| n | Hazard Ratio (95% CI) | p Value | |
|---|---|---|---|
| Baseline FVC, % predicted | 68 | 0.21 (0.01–8.61) | 0.408 |
| Baseline WD, 100 feet units | 68 | 0.96 (0.82–1.13) | 0.644 |
| Decrease FVC (% predicted) relative change > 10% | 13 | 3.01 (1.03–8.79) | 0.043 |
| Increase in FVC (% predicted) relative change or decrease < 10% | 55 | 1.00 | REF |
| Decrease in WD > 200 ft | 17 | 5.12 (1.70–15.36) | 0.004 |
| Increase in WD or decrease < 200 ft | 51 | 1.00 | REF |
| Baseline FVC, % predicted | 69 | 0.34 (0.02–7.19) | 0.490 |
| Baseline DA, 10 U | 69 | 2.03 (1.24–3.31) | 0.005 |
| Decrease FVC (% predicted) relative change > 10% | 14 | 3.98 (1.27–12.46) | 0.018 |
| Increase in FVC (% predicted) relative change or decrease < 10% | 55 | 1.00 | REF |
| DA relative change, 10% U | 69 | 1.10 (1.02–1.19) | 0.019 |
| Baseline FVC, % predicted | 70 | 0.23 (0.01–9.09) | 0.436 |
| Baseline DlCO, % predicted | 70 | 0.04 (0.01–1.24) | 0.066 |
| Decrease FVC (% predicted) relative change > 10% | 15 | 4.82 (1.30–17.81) | 0.018 |
| Increase in FVC (% predicted) relative change or decrease < 10% | 55 | 1.00 | REF |
| Decrease in DlCO (% predicted) relative change > 15% | 10 | 1.39 (0.46–4.18) | 0.559 |
| Increase in DlCO (% predicted) relative change or decrease < 15% | 60 | 1.00 | REF |
| Baseline DA, 10 U | 62 | 2.59 (1.35–4.95) | 0.004 |
| Baseline DlCO, % predicted | 62 | 2.42 (0.05–117.02) | 0.656 |
| DA relative change, 10% U | 62 | 1.17 (1.05–1.30) | 0.004 |
| Decrease in DlCO (% predicted) relative change > 15% | 9 | 1.06 (1.00–1.12) | 0.101 |
| Increase in DlCO (% predicted) relative change or decrease < 15% | 53 | 1.00 | REF |
| Baseline DlCO, % predicted | 60 | 0.07 (0.01–3.41) | 0.177 |
| Baseline WD, 100 feet units | 60 | 0.87 (0.75–0.99) | 0.044 |
| Decrease in DlCO (% predicted) relative change > 15% | 8 | 6.47 (1.68–24.87) | 0.007 |
| Increase in DlCO (% predicted) relative change or decrease < 15% | 52 | 1.00 | REF |
| Decrease in WD > 200 ft | 15 | 7.94 (2.28–27.65) | 0.001 |
| Increase in WD or decrease < 200 ft | 45 | 1.00 | REF |
| Baseline DA, 10 U | 68 | 1.40 (0.79–2.48) | 0.253 |
| Baseline WD, 100 feet units | 68 | 0.90 (0.77–1.06) | 0.199 |
| DA relative change, 10% U | 68 | 1.13 (0.99–1.28) | 0.067 |
| Decrease in WD > 200 ft | 17 | 2.38 (0.63–8.96) | 0.201 |
| Increase in WD or decrease < 200 ft | 51 | 1.00 | REF |
For definition of abbreviations, see Table 2.
Values are adjusted for age, sex, and smoking history at baseline.