TABLE 1.
PATIENT CHARACTERISTICS FOR PROTEASOME ACTIVITY, E3-LIGASE, CASPASE-3 ACTIVITY, AND WESTERN BLOTTING STUDIES
| Proteasome Activity
|
E3-ligase
|
Caspase-3 Activity
|
Western Blotting
|
|||||
|---|---|---|---|---|---|---|---|---|
| Non-COPD (n = 7) | COPD (n = 7) | Non-COPD (n = 10) | COPD (n = 11) | Non-COPD (n = 7) | COPD (n = 7) | Non-COPD (n = 9) | COPD (n = 9) | |
| Male/female | 6/1 | 6/1 | 9/1 | 9/2 | 6/1 | 7/0 | 8/1 | 9/0 |
| Age, yr | 64 ± 3 | 66 ± 2 | 63 ± 3 | 65 ± 3 | 66 ± 3 | 68 ± 2 | 65 ± 3 | 66 ± 2 |
| BMI, kg · m−2 | 28 ± 1 | 28 ± 2 | 28 ± 1 | 26 ± 2 | 28 ± 1 | 28 ± 2 | 28 ± 1 | 27 ± 2 |
| FEV1, % predicted | 93 ± 4 | 66 ± 7 | 98 ± 4 | 63 ± 4 | 97 ± 4 | 70 ± 7 | 96 ± 4 | 67 ± 6 |
| VC, % predicted | 91 ± 4 | 93 ± 4 | 88 ± 4 | 83 ± 6 | 95 ± 5 | 96 ± 6 | 91 ± 4 | 95 ± 5 |
| FEV1/VC, % | 77 ± 2 | 56 ± 3 | 76 ± 2 | 54 ± 2 | 74 ± 1 | 55 ± 3 | 76 ± 2 | 54 ± 3 |
| TLC, % predicted | 86 ± 3 | 111 ± 4 | 91 ± 4 | 106 ± 4 | 93 ± 5 | 99 ± 4 | 91 ± 4 | 107 ± 5 |
| RV/TLC, % | 33 ± 3 | 47 ± 2 | 38 ± 2 | 47 ± 3 | 36 ± 3 | 45 ± 4 | 37 ± 2 | 44 ± 3 |
| DlCO/Va, % predicted | 103 ± 9 | 78 ± 8 | 112 ± 5 | 76 ± 7 | 92 ± 5 | 84 ± 10 | 103 ± 6 | 79 ± 8 |
| PaO2, kPa | 11.2 ± 0.3 | 10.2 ± 0.5 | 10.2 ± 0.5 | 10.5 ± 0.5 | 10.3 ± 0.6 | 10.6 ± 0.6 | 10.2 ± 0.5 | 10.4 ± 0.3 |
| PaCO2, kPa | 4.8 ± 0.1 | 5.1 ± 0.1 | 4.7 ± 0.1 | 5.0 ± 0.2 | 4.6 ± 0.1 | 4.8 ± 0.2 | 4.7 ± 0.1 | 5.2 ± 0.2 |
Definition of abbreviations: BMI = body mass index; DlCO/Va = carbon monoxide transfer coefficient per alveolar volume; TLC = total lung capacity.
Values represent means ± SEM.