TABLE 2.
HAPLOTYPE FREQUENCY IN WHITES AND AFRICAN AMERICANS
| Polymorphism
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drysdale Haplotype | −3459* | −3308 | −3291 | −3287 | −3251 | −3159 | −2633 | −2387* | −2274 | −1818* | −1531 | −1429 | −1343 | −1023 | −709 | −654 | −468* | −406 | −367 | −262 | −47* | −20 | p46* | p79* | p252 | p491* | p523* | p659* | p1053* | p1239 | p1268 | +1269* | CCFEQ | AAFEQ | |
| 1 | 1-1 | T | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | C | C | T | G | T | T | A | C | G | C | C | C | G | A | C | 13 | 0.00 | 0.14 |
| 1-2 | T | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | C | C | T | G | T | T | A | C | G | C | C | C | G | A | C | 14 | 0.00 | 0.02 | |
| 1-3 | T | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | C | C | T | G | T | T | A | C | G | C | C | C | G | G | G | 12 | 0.00 | 0.01 | |
| 0.00 | 0.17 | ||||||||||||||||||||||||||||||||||
| 2 | 2-1 | C | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | G | C | C | G | C | C | G | G | G | C | C | C | G | G | C | 11 | 0.30 | 0.04 |
| 2-2 | C | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | G | C | C | G | C | C | G | G | G | C | C | C | G | G | C | 10 | 0.03 | 0.00 | |
| 2-2 | C | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | G | C | C | G | C | C | G | G | G | C | C | C | G | G | C | 12 | 0.02 | 0.01 | |
| 2-4 | C | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | G | C | C | G | C | C | G | G | G | C | C | C | G | A | C | 13 | 0.02 | 0.00 | |
| 2-5 | C | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | G | C | C | G | C | C | G | G | G | C | C | C | C | A | C | 13 | 0.01 | 0.01 | |
| 2-6 | C | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | G | C | C | A | C | C | G | G | G | C | C | C | G | G | C | 13 | 0.00 | 0.04 | |
| 2-7 | C | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | G | C | C | G | C | C | G | G | G | C | C | C | G | G | C | 13 | 0.00 | 0.02 | |
| 0.38 | 0.12 | ||||||||||||||||||||||||||||||||||
| 4 | 4-1 | T | A | T | A | C | T | C | T | T | T | C | T | G | G | C | A | C | C | T | G | T | T | A | C | G | C | C | C | G | G | C | 12 | 0.13 | 0.04 |
| 4-2 | T | A | T | A | C | T | C | T | T | T | C | T | G | G | C | A | C | C | T | G | T | T | A | C | G | C | C | C | G | G | C | 13 | 0.07 | 0.07 | |
| 4-3 | T | A | T | A | C | T | C | T | T | T | C | T | G | G | C | A | C | C | T | G | T | T | A | C | G | C | C | C | C | A | C | 13 | 0.07 | 0.01 | |
| 4-4 | T | A | T | A | C | T | C | T | T | T | C | T | G | G | C | A | C | C | T | G | T | T | A | C | G | C | C | C | G | G | C | 11 | 0.05 | 0.06 | |
| 4-5 | T | A | T | A | C | T | C | T | T | T | C | T | G | G | C | A | C | C | T | G | T | T | A | C | G | C | C | C | G | A | C | 13 | 0.02 | 0.01 | |
| 4-6 | T | A | T | A | C | T | C | T | T | T | C | T | G | G | C | A | C | C | T | G | T | T | A | C | G | C | C | C | G | A | C | 12 | 0.02 | 0.00 | |
| 4-7 | T | A | T | A | C | T | C | T | T | T | C | T | G | G | C | A | C | C | T | G | T | T | A | C | G | C | C | C | C | A | C | 14 | 0.01 | 0.00 | |
| 4-8 | T | C | T | A | C | T | C | T | T | T | C | T | G | G | C | A | C | C | T | G | T | T | A | C | G | C | C | C | G | G | C | 11 | 0.00 | 0.02 | |
| 0.37 | 0.21 | ||||||||||||||||||||||||||||||||||
| 6 | 6-1 | T | A | T | A | C | C | C | T | T | A | T | A | G | G | C | G | C | C | T | G | T | T | G | C | A | C | A | C | C | A | C | 13 | 0.09 | 0.18 |
| 6-2 | T | A | T | A | C | T | C | T | T | A | T | A | G | G | C | G | C | C | T | G | T | T | G | C | A | C | A | C | C | A | C | 13 | 0.02 | 0.10 | |
| 6-3 | T | A | T | A | C | C | C | T | T | A | T | A | G | G | C | G | C | C | T | G | T | T | G | C | A | C | A | C | G | G | C | 12 | 0.01 | 0.00 | |
| 0.12 | 0.28 | ||||||||||||||||||||||||||||||||||
| 7 | 7-1 | T | A | T | A | C | T | C | T | T | A | T | A | G | G | C | G | C | C | T | G | T | T | G | C | A | T | A | C | C | A | C | 13 | 0.02 | 0.00 |
| 0.02 | 0.00 | ||||||||||||||||||||||||||||||||||
| 9 | 9-1 | T | A | C | T | A | T | T | C | C | A | C | T | A | A | C | G | C | T | T | G | T | T | A | C | G | C | C | C | G | G | G | 12 | 0.00 | 0.03 |
| 0.00 | 0.03 | ||||||||||||||||||||||||||||||||||
| 10 | 10-1 | T | A | T | A | C | C | C | T | T | A | T | A | G | G | C | G | C | C | T | G | T | T | G | C | A | C | C | C | C | A | C | 13 | 0.02 | 0.00 |
| 0.02 | 0.00 | ||||||||||||||||||||||||||||||||||
Definition of abbreviations: AAFEQ = haplotype frequency in African Americans; CCFEQ = haplotype frequency in whites.
Frequency ⩾ 0.01. Letters within the boxes indicate polymorphisms studied by Drysdale and coworkers (38) and Taylor and coworkers (56). Letters in bold indicate SNPs that define subhaplotypes.
*
Tagging SNPs used in association study.