TABLE 5.

ADJUSTED ODDS RATIOS OF INCIDENT RESPIRATORY SYMPTOMS AT FOLLOW-UP SURVEY (SAPALDIA 2) AMONG SUBJECTS NEVER EXPOSED TO ETS AND SUBJECTS WITH CONTINUED EXPOSURE TO ETS (SAPALDIA 1 AND 2), ACCORDING TO BRONCHIAL HYPERREACTIVITY STATUS AT BASELINE (SAPALDIA 1)

	Never Exposed to ETS	Continued ETS Exposure
	BHR OR (95% CI) (n = 127)	No BHR OR (95% CI) (n = 106)	BHR OR (95% CI) (n = 19)
Wheeze	1.86 (0.84–4.13)	0.82 (0.29–2.33)	2.73 (0.60–12.3)
Wheeze with dyspnea	1.76 (0.56–5.53)	0.70 (0.14–3.50)	3.73 (0.60–23.4)
Wheeze apart from cold	3.52 (1.13–10.9)*	0.57 (0.10–3.22)	12.3 (2.36–64.2)†
Cough	1.77 (0.86–3.66)	1.59 (0.72–3.53)	5.84 (1.62–21.1)†
Phlegm	0.95 (0.42–2.13)	1.08 (0.47–2.49)	1.59 (0.32–7.87)
Dyspnea	1.02 (0.52–2.00)	1.56 (0.78–3.10)	12.2 (3.52–42.0)‡
Chronic bronchitis	2.66 (1.19–5.93)*	0.71 (0.23–2.24)	7.87 (2.08–29.8)†

For definition of abbreviations, see Table 4.

For this analysis, only subjects who had performed a methacholine bronchoprovocation test are considered; subjects without bronchial hyperreactivity and never exposed to ETS serve as the reference (n = 872). Odds ratios were adjusted for age, sex, body mass index, region, education, nationality, atopy, parental atopy or asthma, occupational exposure, and FEV₁ at baseline. The p values refer to comparisons of the different groups at risk with the reference group.

^*p < 0.05.

^†p < 0.01.

^‡p < 0.0001.