TABLE 3.

ASSOCIATION BETWEEN GLUTAMATE-CYSTEINE LIGASE CATALYTIC SUBUNIT GENOTYPE AND CYSTIC FIBROSIS LUNG FUNCTION (n = 440)

Study Population	Adjusted GCLC Genotype Regression Coefficient (SE)*	p Value
All patients (n = 440)	1.68 (1.0)	0.097
Patients with a severe CFTR genotype (n = 301)	0.77 (1.24)	0.533
Patients with a mild CFTR genotype (n = 139)	5.5 (1.7)	0.001

Definition of abbreviations: CFTR = cystic fibrosis transmembrane conductance regulator; GCLC = glutamate-cysteine ligase catalytic subunit.

^*GCLC genotype is an ordinal variable with 1 = 7/7, 2 = 7/8, 3 = 7/9, 4 = Other/Other. Patients with at least one mutant allele in Class IV, V and Unclassified were considered to have a mild CFTR genotype.