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. Author manuscript; available in PMC: 2009 Feb 26.
Published in final edited form as: Brain Res. 2006 Oct 3;1119(1):26–39. doi: 10.1016/j.brainres.2006.08.078

Fig. 8. ΔRR modulates Bad and Bag-1 expression through activation of the MEK and PI3-K pathways and activates CREB independent of these pathways.

Fig. 8

A, OHC were infected with ΔRR or ΔPK (105 pfu) or mock infected with PBS and cultured with U0126 (U; 20µM) or LY294002 (LY; 100 µM). Extracts obtained at 24 hrs p.i. were immunoblotted with antibody to phosphorylated Bad (P-Bad). The blots were stripped and sequentially re-probed with antibodies to Bad, Bag-1 and actin. B, Duplicates of the extracts in Fig 6 were immunobloted with antibody to phosphorylated CREB (P-CREB). Blots were stripped and re-probed with CREB antibody. C, Data from B expressed as fold increase in P-CREB/CREB ratios relative to mock-infected OHC.