FIG. 1.

Overview of the predicted intertwined regulatory networks of 10 sar family genes and their relationship with the agr locus. This overview is mostly based on genetic and biochemical analyses in strain RN6390 under normal conditions of growth (8, 10, 28-36, 41, 49-52). Several members of the sar family of genes (e.g., sarV, sarT, and sarU) are not transcribed due to repression by other normally expressed sar family genes (32, 33, 49). The pathways identified in this study are depicted by dashed lines. The thickness of the line indicates the nature of regulation: thin, partially involved, and thick, completely involved.