TABLE 1.
Globin gene expression in transgenic micea
| Transgenic line | ɛ-Globin gene expression
|
γ-Globin (Gγ:Aγ) gene expression
|
β-Globin gene expression
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| e10.5 | e12.5 | e14.5 | e10.5 | e12.5 | e14.5 | e16.5 | Newborns | Adults | e12.5 | e14.5 | e16.5 | Newborns | Adults | |
| YAC | 1.0 ± 0.2 | 1.0 ± 0.4 | 1.0 ± 0.6 | 1.0 ± 0.2 | 1.0 ± 0.3 | 1.0 ± 0.4 | 1.0 ± 0.2 | 1.0 ± 0.8 | 1.0 ± 0.9 | 1.00 ± 0.21 | 1.00 ± 0.39 | 1.00 ± 0.17 | 1.00 ± 0.12 | 1.00 ± 0.51 |
| PY367 | 0.8 ± 0.3 | 0.3 ± 0.1 | 1.5 ± 0.6 | 0.8 (0.6:0.2) ± 0.4 | 3.8 (2.7:1.1) ± 0.8 | 12.4 (8.8:3.6) ± 2.6 | 26.0 (15.1:10.9) ± 16.3 | 1.2 (0.6:0.6) ± 0.5 × 102 | 3.7 (2.3:1.4) ± 0.9 × 103 | 0.04 ± 0.01 | 0.04 ± 0.01 | 0.07 ± 0.04 | 0.11 ± 0.03 | 0.07 ± 0.01 |
| PY418 | 1.1 ± 0.4 | 1.0 ± 0.3 | 1.2 ± 0.5 | 1.1 (0.7:0.4) ± 0.5 | 4.2 (3.2:1.0) ± 1.2 | 34.3 (18.9:15.4) ± 9.9 | 31.4 (19.9:11.5) ± 13.9 | 2.8 (1.1:1.8) ± 0.5 × 102 | 11.8 (4.1:7.7) ± 11.5 × 103 | 0.03 ± 0.01 | 0.11 ± 0.05 | 0.46 ± 0.10 | 0.12 ± 0.03 | 0.63 ± 0.46 |
| PY465 | 3.7 ± 2.2 | 3.0 ± 2.1 | 3.3 ± 2.6 | 3.3 (2.4:0.9) ± 1.6 | 20.0 (14.3:5.7) ± 8.1 | 31.4 (22.7:8.7) ± 16.6 | 90.1 (61.4:28.7) ± 58.2 | 2.0 (0.9:1.0) × 102 | 37.9 (22.5:14.8) ± 38.3 × 103 | 0.17 ± 0.10 | 0.13 ± 0.05 | 0.16 ± 0.06 | 0.06 | 0.79 ± 0.58 |
a
Expression is expressed relative to that in β-YAC wild-type mice.