TABLE 1.
NF-κB activation by HHV-8 genes/gene combinations
| Genes | NF-κB activation
|
Adjusted P value | |
|---|---|---|---|
| Fca | Rangeb | ||
| K13 + ORF73 | 6.2 | 2.8-14.8 | 0.0002 |
| pcDNA + K13 | 3.9 | 0.6-13.2 | 0.0003 |
| K13 + K13 | 3.8 | 1.9-10.1 | 0.0002 |
| pcDNA + LMP-1c | 3.8 | 1.2-6.2 | 0.0002 |
| K13 + K3 | 3.0 | 0.9-3.8 | 0.0003 |
| K13 + K11 | 3.0 | 1.6-5.8 | 0.0002 |
| K13 + K5 | 2.9 | 1.5-5.2 | 0.0002 |
| K13 + K15 | 2.9 | 1.5-4.7 | 0.0002 |
| pcDNA + ORF75 | 2.6 | 1.5-4.7 | 0.0002 |
| K13 + K4 | 2.5 | 0.8-4.3 | 0.0005 |
| K13 + K2 | 2.4 | 0.9-6.3 | 0.0003 |
| K13 + ORF72 | 2.3 | 1.4-7.5 | 0.0002 |
a
The fc values were determined in comparison to the results for transfections with pcDNA alone.
b
RTCM results were obtained for 38 replications.
c
The LMP-1 gene was used as a positive control for NF-κB activation.