TABLE 2.

NF-κB inhibition by HHV-8 genes

Analytical method	Gene		NF-κB inhibition		P value
	Activating	Inhibitory	Fca	Rangeb
RTCM	LMP-1	K14	0.50	0.22-1.62	0.01
		K10.5	0.48	0.28-1.39	0.01
		K9	0.41	0.18-2.09	0.01
		K1	0.38	0.26-1.25	0.01
Classical transfection	LMP-1	K14	0.41	0.35-0.49	0.001
		K1	0.35	0.32-0.39	0.001
		K9	0.27	0.21-0.31	0.001
		K10.5	0.17	0.14-0.20	0.001
	K13	K9	0.65	0.61-0.69	0.001
		K14	0.62	0.58-0.65	0.001
		K10.5	0.48	0.44-0.50	0.001
		K1	0.40	0.37-0.43	0.001

^aThe fc values were determined in comparison to those for transfections with the activator (the LMP-1 gene or K13) alone. The threshold for significant inhibition of LMP-1 gene- or K13-induced NF-κB activation was set to an fc of ≤0.50 and a P value of ≤0.05.

^bRTCM results were obtained for 38 replications.