FIG. 3.

Protection of mice from lethal H5N1 viral challenge after pretreatment with MAbs. Each group of mice was pretreated intraperitoneally with 10 mg/kg, 5 mg/kg, or 0 mg/kg (PBS) of MAb 1C9 or 1B12 1 day before challenge with mouse-adapted Indonesian HPAI H5N1 strains, either A/Vietnam/1203/04 clade 1.0 virus (a) or A/TLL013/06 clade 2.1 virus (b and c). Mice were monitored for survival (a and b) throughout a 14-day observation period. The results are expressed in terms of percent survival. (c) Mice were monitored for weight loss throughout the 14-day observation period. The results are expressed in terms of percent body weight (at the beginning of the trial).