TABLE 3.
Neutralizing antibodies in rhesus animals after primary infection prior to superinfection
Animal | Primary virus | No. of days of infection | ID50 ina:
|
|
---|---|---|---|---|
TZM-bl cells infected with SIVmac251/CS.41b | 5.25.EGFP.Luc.M7 cells infected with SIVsmE660c | |||
CP3C | SIVsmE660 | 768 | <20 | 92 |
CG7G | SIVsmE660 | 775 | <20 | 508 |
AK9F | SIVsmE660 | 748 | 20 | 136 |
CP23 | SIVsmE660 | 768 | 37 | 62 |
CR54 | SIVsmE660 | 105 | <20 | <20 |
CP37 | SIVsmE660 | 105 | 41 | 79 |
CP1W | SIVmac251 | 775 | 43 | 245 |
CT76 | SIVmac251 | 775 | 50 | 110 |
PBE | SIVmac251 | 748 | 50 | <20 |
CG71 | SIVmac251 | 105 | <20 | 188 |
AH4X | SIVmac251 | 365 | 33 | 120 |
CR53 | SIVmac251 | 762 | 215 | <20 |
AV74d | SIVmac251 | 105 | <20 | 73 |
CG5Gd | SIVmac251 | 105 | <20 | 124 |
Values are the sample serum dilution at which relative luminescence units (RLU) were reduced 50% compared to virus control wells (no serum sample).
Pseudoviruses containing Env cloned from single expansion of uncloned SIVmac251 challenge stock were generated in 293T cells.
Uncloned SIVsmE660 virus stock was generated in CEMx174 cells.
Results for monkeys who resisted superinfection are highlighted in boldface.