TABLE 2.
Virus loads, slopes of CD4 T-cell decline, and potential CTL escape mutations in patients in this study
| Patient ID | Viral load at entry (copies/ml) | Viral load at set point (copies/ml)a | CD4 slope (cells/μl) | No. of CTL epitopes in first available sampleb
|
|||
|---|---|---|---|---|---|---|---|
| Mutant CTL epitopes
|
Sensitive CTL epitopes
|
||||||
| PR | RT | PR | RT | ||||
| 3021 | 3,782 | 63,265 | −0.16 | 1 | 8d | 1 | 1 |
| 3024 | 115,721 | 173,550 | −0.31c | 3d | 8d | 0 | 4 |
| 3036 | 40,912 | 61,459 | −0.81 | 4d | 5d | 3 | 14 |
| 3037 | 47,272 | 82,106 | −0.28c | 5 | 7 | NA | NA |
| 3041 | 143,505 | 21,248 | −0.07 | 1 | 4d | 3 | 6 |
| 3062 | 34,299 | 19,476 | −0.08c | 2d | 3d | 1 | 7 |
| 3077 | 187,982 | 722,926 | 0.3 | 3d | 4d | 4 | 12 |
| 3088 | 1,392,011 | 470,189 | −0.55 | 2 | 7 | NA | NA |
| 1001 | 300,815 | 136,647 | −0.46c | 5d | 10d | 1 | 2 |
| 1002 | 671,679 | 17,317 | −1.21 | 2 | 4 | NA | NA |
| 1003 | 110,000,000 | 453,737e | −0.89c | 4 | 8 | NA | NA |
| 1004 | 9,347,800 | 67,989 | −0.26 | 1 | 8 | NA | NA |
| 1005 | 750,000 | 52,148 | −0.11c | 2 | 4 | NA | NA |
| 1006 | 500,000 | 22,876 | 0.46 | 3 | 6 | NA | NA |
a
Mean viral load at 3 months postseronconversion.
b
Values in bold indicate that the HLA type is known. NA, not available.
c
CD4 count declined to <200 during the observation period.
d
Mutant CTL epitopes matched patient HLA type.
e
Only a single sample was available at 3 months postseroconversion.