TABLE 3.

CTL mutations in protease

Codon in PR	Consensus B residue	Residue in virus from patienta:
		3024			3062			3021			3041			3036			3077			3037			3088			1001b		1002		1003b		1004		1005b		1006
		M0	M21	M38	M7	M16	M31	M9	M30	M59	M3	M18	M32	M6	M13	M22	M5	M22	M37	M8	M16	M38	M6	M18	M23	D0	D138	D0	D287	D0	D110	D0	D489	D0	D1253	D0	D220
10	L																									I	L/I
12	T	E	E	E				S	S	S/P																						A	A, T
13	I	V	V	V																										I/V	I/V	V	V
15	I	V	V	V/I										V	V	V				A/N/I	A/V/I	V/I
16	G													E	E	E
19	L													I	I/K	I/K	I	I	I	I/T	I	I
20	K																													K/R	K/R
34	E																									D	E/D
35	E	D	D	D/E	D/E	D/E	D/E													D	D	D						N	N/T
36	M				I	I/T	I/L							L	L	L				S	S	S	I/T	I/T/V	I/M					M/I	M/I					I	I/V
37	N	H	H/Q	H/P	S/N/D	S/N	S/N/D	S/N/A	S/N/T/H	S/N/A/Q				S	S/N	S	E	E	E				S/N/H	S/N/H/T	S/N			D	D					S	S	S	S
39	P				P/L	P/L	P							S	S	S
41	R				R/K/G	R/K	K							K	K	K				K	K	K	R/K	K	K					K	K			K	K
45	K																			R	R	R/K
46	M																									I	M/I
57	R										K	K	K							K	K	K								K/R	K/R
62	I													V	V	V							V	V	V	V	I/V									V	V
63	L	P	P	P	P	P	P	P/H	P/H/T	P/H	P	P	P	Q	Q	Q	P	P	P	P	P	P	Q	Q	Q/P			P	P	P	P	P	P	P/L	P	P	P
64	I									I/L				V	V	V										V	M/V
69	H																N	N	N
70	K																R	R	R																	T	T,/A
71	A																											T	T
72	I																													I/E	I/E
77	V																									I	M/I							V/I	I
82	V																																			I	I
85	I																									V	I/V
90	L
92	Q													K/R	K/R	K/R										M	L/M
93	I										L	L	L							L	L	L				L	L							L	L	L	L

^aResidues in bold indicate previously defined CTL escape mutations (5, 25).

^bMultiple-variant transmission or superinfection.