TABLE 3.

EFFECTS OF GSTM1 AND GSTP1 GENOTYPES ON MEDIAN DIFFERENCES IN NASAL ALLERGIC RESPONSES BETWEEN CLEAN AIR PLUS ALLERGEN AND SECONDHAND SMOKE EXPOSURE PLUS ALLERGEN^*

		Median Difference (min∼max)
Genotyping	n	IgE (U/ml)	IL-4 (U/ml)	IFN-γ (ng/L)	Histamine (nM)
GSTM1
Present	5	46.7 (8.9∼95.0)	3.2 (0.0∼5.4)	−0.2 (−1.0∼−0.1)	8.4 (−0.9∼10.2)
Null	14	173.3 (11.3∼725.5)	4.0 (−0.4∼13.1)	−0.2 (−1.5∼0.1)	9.4 (−0.9∼20.6)
p Value†		0.03	0.33	0.61	0.43
GSTP1
Ile/Ile	13	162.2 (24.6∼725.5)	2.9 (0.0∼13.1)	−0.2 (−0.9∼0.1)	10.2 (2.3∼20.6)
Ile/Val	6	51.0 (8.9∼423.6)	3.3 (−0.4∼12.2)	−0.5 (−1.5∼−0.1)	4.6 (−0.9∼10.1)
p Value†		0.07	0.93	0.20	0.03

^*Level after secondhand smoke exposure plus allergen minus level after clean air plus allergen.

^†Two-sided Wilcoxon rank sum test. Histamine values were collected in lavages at 10 min, and other responses at 4 d, after challenge.