TABLE 5.
CORRELATION OF DIFFERENCES IN NASAL ALLERGIC ENDPOINTS WHEN EXPOSED TO CLEAN AIR PLUS ALLERGEN OR SECONDHAND SMOKE EXPOSURE PLUS ALLERGEN VERSUS CLEAN AIR PLUS ALLERGEN OR DIESEL EXHAUST PARTICLES PLUS ALLERGEN
| Response*
|
||||
|---|---|---|---|---|
| IgE | IL-4 | Histamine | IFN-γ | |
| All (n = 19) | 0.62 (0.005) | 0.79 (< 0.0001) | 0.54 (0.02) | 0.63 (0.005) |
| By GSTM1 genotypes | ||||
| GSTM1 present (n = 5) | 0.87 (0.07) | 0.95 (0.02) | 0.34 (0.58) | 0.79 (0.11) |
| GSTM1 null (n = 14) | 0.54 (0.04) | 0.74 (0.003) | 0.51 (0.07) | 0.58 (0.03) |
| By GSTP1 genotypes | ||||
| GSTP1 Ile/Ile (n = 13) | 0.62 (0.03) | 0.73 (0.005) | 0.37 (0.22) | 0.75 (0.003) |
| GSTP1 Ile/Val (n = 6) | 0.45 (0.37) | 0.91 (0.01) | 0.36 (0.49) | 0.77 (0.07) |
*
Values presented are correlations (p values for H0: ρ = 0).
The data concerning diesel exhaust particles have been published previously (9). Histamine values were collected in lavages at 10 min, and other responses at 4 d, after challenge.