. Author manuscript; available in PMC: 2009 Feb 26.

Published in final edited form as: Bioorg Med Chem Lett. 2007 Apr 25;17(13):3642–3646. doi: 10.1016/j.bmcl.2007.04.058

Table 1.

Stability of C-10 esters Vs C-10 carbamates

Cpd	PBS t_½ (hr)	Human plasma t_½ (hr)	Mouse plasma t_½ (hr)

Paclitaxel	>60 (85.2%)^a	18.2	30.1
TX-67	>60 (75.1%)^a	15.3	19.5
CNDR-3	>60 (91.6%)^a	52.0	31.3

Percentage of remaining compound after 24 h.