. Author manuscript; available in PMC: 2009 Feb 26.

Published in final edited form as: Bioorg Med Chem Lett. 2007 Apr 25;17(13):3642–3646. doi: 10.1016/j.bmcl.2007.04.058

Table 2.

Recovery and Apparent Permeability (10^-6 cm/s) of digoxin in the presence of representative paclitaxel and docetaxel C-10 carbamates

Test Compound	Recovery (%)		Papp^a (10^-6 cm/s)						Efflux Ratio^b

	A-B	B-A	A-B			B-A

			R1	R2	AVG	R1	R2	AVG
Digoxin Alone	98	101	0.21	0.14	0.18	6.05	7.97	7.01	39
Digoxin + CNDR-3	78	81	0.23	0.17	0.2	5.66	6.68	6.17	31
Digoxin + CNDR-5	102	96	0.13	0.17	0.15	7.14	7.95	7.54	50
Digoxin + CNDR-29	90	94	0.23	0.16	0.19	7.55	11.8	9.67	50

Apparent permeability coefficient;²¹

Efflux ratio = Papp(B-A)/Papp(A-B) across monolayers of MDR-MDCK